Practolol

Drug #592

Practolol is a cardio-selective beta receptor blocking drug. Nowadays Practolol is not used because of its toxic effect on eyes and ear.

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Primary Characteristics

It is of Synthetic origin and belongs to Acetanilide.

It belongs to Beta-1 adrenergic antagonist pharmacological group on the basis of mechanism of action and also classified in Antihypertensive Agents pharmacological group.

Molecular Weight: 266.3 · pK_a: 9.5 · Solubility in Water: 1:400 · Solubility in Alcohol: 1:40 · Non-proprietary name: Practolol.

Pharmacokinetics

Absorption: Practolol has an oral bioavailability is 96.5% (±1.5%), pre-systemic (first-pass) metabolism accounts for 3% (±2%).

Distribution: Practolol has a volume of distribution is 1.6 l/kg. plasma protein binding is < 5 %.

Elimination: plasma half-life is 10 - 13 hr, renal excretion is 100 %.

Indications

Practolol is primarily indicated in conditions like Angina, Cardiac arrhythmia.

Contraindications

Practolol is contraindicated in conditions like Acidosis, Cardiogenic shock, Heart block, Bradycardia, Refractory heart failure.

Dosage

Practolol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.18 mg/kg	0.18 mg/kg	—	IV	As Required
2.41 mg/kg	2.41 mg/kg	Every 8h	PO	-
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Practolol in overdosage may give rise to further complications which include Practolol induced syndrome, Heart failure , SLE-like syndrome.

The signs and symptoms that are produced after acute overdosage of Practolol are Bradycardia.

Practolol is known to cause more or less tolerable side effects which are usually transient. These include Bradycardia , Bronchospasm, Constipation , Dizziness, Hypotension , Nausea, Paresthesias.

Warnings / Precautions

The drug should not be used in sinus bradycardia, when heart block is more than 1st degree, cardiogenic shock and cardiac failure.

Available Brands

None recorded.

Storage Conditions

Practolol should be stored .

Drug Classification

1.12.3.1 — Beta blocking agents