Porcine Insulin

Drug #588

Porcine Insulin is a type of soluble Insulin extracted from the pancreas of porcus a pig or hog, contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. It differs from human insulin in only one amino acid in the beta chain. Porcine Insulin is a short-acting form of insulin, used in the management of diabetes mellitus, and diabetic ketoacidosis.

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Primary Characteristics

It is of Natural origin and belongs to Polypeptide.

It belongs to Insulin agonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Insulin pharmacological group.

Molecular Weight: 5777.6 · Solubility in Water: > 1 in 1000 · Solubility in Alcohol: < 1 in 10000 · Non-proprietary name: Porcine Insulin.

Pharmacokinetics

Absorption: Porcine Insulin has an pre-systemic (first-pass) metabolism accounts for 50% (±50%).

Distribution: Porcine Insulin has a volume of distribution is 70 - 140 ml/Kg. plasma protein binding is 5 %.

Elimination: it is metabolised via Hepatic and Renal, plasma half-life is 4 -5 min, renal excretion is 20 %.

Indications

Porcine Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalaemia.

Contraindications

Porcine Insulin is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Porcine Insulin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.125 IU/kg	0.125 IU/kg	Every 12h	IV	Dose depends upon Blood Sugar Level
7.5 IU/kg	7.5 IU/kg	Every 12h	SC	Dose depends upon Blood Sugar Level
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown10 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Porcine Insulin produces potentially life-threatening effects which include Hypoglycemia , Hypoglycemia. Careful monitoring is needed with proper medical management.

Porcine Insulin is known to cause more or less tolerable side effects which are usually transient. These include Lipohypertrophy .

Warnings / Precautions

Patients should be instructed regarding their dosage and should be reminded that this formulation requires the administration of a smaller volume of solution than is the case with less concentrated formulations.

Interference in Pathology

Porcine Insulin may interfere in the diagnosis of Monitoring of blood and urine glucose.

Available Brands

None recorded.

Storage Conditions

Porcine Insulin should be stored Inj .

Drug Classification

1.18.7.1 — Insulins