Phenoperidine (HCl)
Phenoperidine (HCl) is a narcotic analgesic, used to relieve moderate to severe pain. Phenoperidine (HCl) is used with droperidol to produce neuroleptanalgesia (a state of consciousness with calmness allowing the patient to co-operate with surgeon).
Primary Characteristics
It is of Synthetic origin and belongs to Opioid.
It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic-Narcotic pharmacological group. It is also classified under General Anesthetics .
Molecular Weight: 403.9 · pKa: 8.01 · Solubility in Water: null · Solubility in Alcohol: 1 in 10 · Non-proprietary name: Phenoperidine (HCl).
Pharmacokinetics
Absorption: Phenoperidine (HCl) has an oral bioavailability is 12% (±2%).
Distribution: Phenoperidine (HCl) has a volume of distribution is 5.7 l/kg. plasma protein binding is 80 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 3.2 hr, renal excretion is 5 %.
Advertisement
Indications
Phenoperidine (HCl) is primarily indicated in conditions like Pain.
Phenoperidine (HCl) is also indicated for secondary conditions like Anesthesia, Surgery.
Contraindications
Phenoperidine (HCl) is contraindicated in conditions like Renal diseases, Respiratory disease, Hepatic disease.
Dosage
Phenoperidine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.049 mg/kg | 0.049 mg/kg | — | IV | As Required |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Phenoperidine (HCl) produces potentially life-threatening effects which include Respiratory depression, Severe Hypotension . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Phenoperidine (HCl) are Cyanosis, Cardiac arrest.
Phenoperidine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Bad dreams, Bradycardia , Constipation , Itching, Mood swings, Muscle rigidity, Nausea, Sedation , Urinary retensionX.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.2.2 — Opioid analgesics