Oxaminiquine
Oxaminiquine is anthelmintic agent. Oxaminiquine is a semisynthetic tetranhydroquinoline. Chemically Oxaminiquine is 1,2,3,4-tetrahydro-2-[[(1-methylethyl) amino] methyl]-7-nitro-6-quinoline-methanol. Oxaminiquine is the safe and active against all stages of Schistosomiasis. Oxaminiquine is administered orally.
Primary Characteristics
It is of Synthetic origin and belongs to Quinoline.
It is classified in Anthelmintics pharmacological group.
Molecular Weight: 279.3 · Solubility in Water: 1 in 3300 · Solubility in Alcohol: soluble · Non-proprietary name: Oxaminiquine · pH: 8.
Pharmacokinetics
Absorption: Oxaminiquine has an oral bioavailability is 60.5% (±9.5%).
Elimination: it is metabolised via extensively by Liver, plasma half-life is 1.125 hr, renal excretion is 58 %.
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Indications
Oxaminiquine is primarily indicated in conditions like Schistosomiasis.
Contraindications
Oxaminiquine is contraindicated in conditions like Epilepsy.
Dosage
Oxaminiquine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 17.5 mg/kg | 17.5 mg/kg | — | PO | Once, over 2 to 3 days |
| Paediatric Dosage (20kg) | ||||
| 12.5 mg/kg | 12.5 mg/kg | Every 12h | Oral | For 1-3 Days |
| Neonatal Dosage (3kg) | ||||
| 12.5 mg/kg | 12.5 mg/kg | Every 12h | Oral | For 1-3 Days |
Drug Interactions
None recorded.
Side Effects
Oxaminiquine in overdosage may give rise to further complications which include Hallucinations , Psychosis , Seizures .
The signs and symptoms that are produced after acute overdosage of Oxaminiquine are Convulsions .
Oxaminiquine is known to cause more or less tolerable side effects which are usually transient. These include Discoloration of urine, Dizziness, Drowsiness, Headache.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.1.3 — Antischistosomals and other anti-trematodes