Nifurtimox
Nifurtimox is the first compound that proved effective in human therapy of the South American trypanosomiasis caused by Trypanosoma cruzi. Chemically itidentified as 3-methyl-N-[(5-niro-2-furanyl) methylene]-4-thiomorpholinamine-1, 2-dioxide. Nifurtimox is tripanocidal against both amastigote and tripomasigote form of Trypanosoma cruzi. iteffective against both acute as well as chronic phase of infection. it is prepared by chemical synthesis. itadministerd orally.
Primary Characteristics
It is of Synthetic origin and belongs to Nitrofurane.
It belongs to Antiparasitic pharmacological group on the basis of mechanism of action.
Molecular Weight: 287.3 · Solubility in Water: 1 in 20 · Non-proprietary name: Nifurtimox.
Pharmacokinetics
None recorded.
Advertisement
Indications
Nifurtimox is primarily indicated in conditions like Leishmaniasis, Onchoceriasis, Trypanosomiasis.
Contraindications
Nifurtimox is contraindicated in conditions like Convulsions, Cerebral impairment.
Dosage
Nifurtimox's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 9 mg/kg | 9 mg/kg | Every 24h | PO | - |
| Paediatric Dosage (20kg) | ||||
| 15 – 20 mg/kg | — | Every 24h | ||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Nifurtimox in overdosage may give rise to further complications which include Convulsions , Insomnia , Psychosis , Disorientation , Disturbance of equilibrium .
Nifurtimox produces potentially life-threatening effects which include Leucopenia . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Nifurtimox are Excitation , Gastralgia.
Nifurtimox is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , dizziness, Exanthema , Headache, Morbiliform, Myalgia, Nausea, Neuralgia , Paresthesias, Skin rash, Urticaria, Vomiting .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.4.4 — Antitrypanosomal drugs