Nefopam (HCl)
Also known as: Benzoxazocine, Fenazoxine
Nefopam (HCl) is analgesic agent for the treatment of moderate to moderately severe pain. Nefopam (HCl) is chemically and pharmacologically distinct from any other class of analgesic. Chemically Nefopam (HCl) is identified as 3, 4, 5, 6-tetrahydro-5-methyl-1-phenyl-1H-2, 5-benzoxazocine hdrochloride. Nefopam (HCl) is prepared by chemical synthesis and has a unique hetrocyclic structure. Nefopam (HCl) is asdministered orally and parentrally.
Primary Characteristics
Nefopam (HCl) is also known as Benzoxazocine, Fenazoxine.
It is of Synthetic origin and belongs to Benzoxazocine.
It belongs to Amine uptake inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesic pharmacological group.
Molecular Weight: 289.8 · pKa: 9.2 · Solubility in Water: 1 in 43 · Solubility in Alcohol: 1 in 312 · Non-proprietary name: Nefopam (HCl).
Pharmacokinetics
Absorption: Nefopam (HCl) has an oral bioavailability is 97.5% (±2.5%), pre-systemic (first-pass) metabolism accounts for 83% (±7%).
Distribution: Nefopam (HCl) has a volume of distribution is 10 l/kg. plasma protein binding is 71-76%.
Elimination: it is metabolised via extensive, plasma half-life is 4 hr, renal excretion is 87 %.
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Indications
Nefopam (HCl) is primarily indicated in conditions like Before surgery in women who have anaemia due to uterine fibroids, Pain.
Nefopam (HCl) is also indicated for secondary conditions like Cancer, Surgery.
Contraindications
Nefopam (HCl) is contraindicated in conditions like Epilepsy, Glucoma, Myocardial infarction, Urinary retention (adynamic bladder), Prostatic hypertrophy, Convulsions.
Dosage
Nefopam (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 75 mg | 75 mg | Every 8h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Nefopam (HCl) in overdosage may give rise to further complications which include Convulsions , Hallucinations , Hallucinations .
The signs and symptoms that are produced after acute overdosage of Nefopam (HCl) are Tachycardia , Convulsions , Hematuria, Hallucinations , Agitation, Coagulopathy, Patch necrosis of GI mucosa, Cerebral edema, Agitation.
Nefopam (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Anxiety, Dry mouth, Dysphonia, Euphoria, Headache, Nausea, Sleep disturbance, SweatingX, Syncope .
Warnings / Precautions
Interference in Pathology
Nefopam (HCl) may interfere in the diagnosis of Chromatographic Analysis of Codein, Diazepam & Pentazocine .
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)