Amodiaquine
Amodiaquine is a 4-aminoquinoline antimalarial with an action and uses similar to that of chloroquine. Amodiaquine is not recommended for the prophylaxis of malaria. Amodiaquine is used to treat malaria (intermittent or remittent disease characterized by attacks of chills, fever, and sweating and caused by a parasitic protozoan transferred to the human bloodstream by an anopheles mosquito).
Primary Characteristics
Amodiaquine is also known as Amodiaquine HCl.
It is of Synthetic origin and belongs to Quinoline Phenol.
It belongs to Antiplasmodial pharmacological group on the basis of mechanism of action and also classified in Antimalarial Agent pharmacological group.
Molecular Weight: 464.8 · Solubility in Water: 1 in 22 · Solubility in Alcohol: 1 in 70 · Non-proprietary name: Amodiaquine.
Pharmacokinetics
Absorption: Amodiaquine has an oral bioavailability is 82.5% (±2.5%), pre-systemic (first-pass) metabolism accounts for 82.5% (±2.5%).
Distribution: Amodiaquine has a plasma protein binding is extensive.
Elimination: it is metabolised via via liver, plasma half-life is 5.2 hr.
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Indications
Amodiaquine is primarily indicated in conditions like Malaria, Nephrogenic and partial pituitary diabetes insipidus.
Contraindications
Amodiaquine is contraindicated in conditions like Malaria prophylaxis.
Dosage
Amodiaquine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 35 mg/kg | 35 mg/kg | — | PO | For 3 days. |
| Paediatric Dosage (20kg) | ||||
| 7.5 mg/kg | 7.5 mg/kg | — | Oral | Once a Week |
| Neonatal Dosage (3kg) | ||||
| 6.25 mg/kg | 6.25 mg/kg | — | oral | Once a week |
Drug Interactions
None recorded.
Side Effects
Amodiaquine in overdosage may give rise to further complications which include Liver damage .
Amodiaquine produces potentially life-threatening effects which include Blood dyscrasias, Lupus erythematosus. Careful monitoring is needed with proper medical management.
Amodiaquine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Diarrhea, General malaise, Irregular heart beat, Nail-beds pigmentation, Nausea, Palate pigmentation, Skin pigmentation, Termors, Tinnitus, Vomiting , Weakness.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.6.4.3 — Antimalarials
Manufacturers
Manufacturers of Amodiaquine in Pakistan: