Amlodipine (Besylate)
Amlodipine (Besylate) is a calcium channel blocker. It lowers the blood pressure, relaxes heart muscles and dilates the heart blood vessels to prevent spasm. It has been known since the late 1800s that calcium influx was necessary for the contraction of muscle.it inhibits the calcium influx across the cell membrane.it was approved by FDA in july1992 for clinical use.its long duration of action allows once daily dosage.
Primary Characteristics
Amlodipine (Besylate) is also known as Amlodipine.
It is of Synthetic origin.
It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action.
Non-proprietary name: Lacosamide.
Pharmacokinetics
None recorded.
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Indications
Amlodipine (Besylate) is primarily indicated in conditions like Angina pectoris, Essential hypertension, Hypertension, Prophylaxis of angina, Vasospastic angina.
Contraindications
Amlodipine (Besylate) is contraindicated in conditions like Aortic stenosis, Sinoatrial node disease, Hypersensitivity.
Dosage
Amlodipine (Besylate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 7.5 mg | 7.5 mg | Every 24h | PO | Use 2.5 mg/dose QD PO, in small & fragile geriatric patients or those with hepatic insufficiency.Maximum dose: 10 mg/24hr |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Amlodipine (Besylate) in overdosage may give rise to further complications which include Sinus bradycardia , Peripheral edema.
Amlodipine (Besylate) produces potentially life-threatening effects which include Myocardial infarction. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Amlodipine (Besylate) are Conduction system Delay, Hypotension, Bradyarrhythmias, Congestive heart failure.
Amlodipine (Besylate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Blurred vision, Constipation , Coughing, Diarrhea, Dizziness, Drowsiness, dysthesia, Facial flushing, Fatigue, Flatulence, Flushing, Headache, Hypotension , Nausea, Palpitation, Peripheral edema, Skin erythema, Syncope , Tremors, Vertigo, Vomiting , Wheezing .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.12.3.2 — Calcium antagonists
Manufacturers
Manufacturers of Amlodipine (Besylate) in Pakistan: