Methohexitone (Na)
Methohexitone (Na) is ultra short acting barbiturate hypnotic and used for the induction of anesthesia. Actions and adverse effects similar to thiopentone sodium.
Primary Characteristics
It belongs to Barbiturate.
It belongs to Chloride Channel opener (Gaba operated) pharmacological group on the basis of mechanism of action. It is also classified under General Anesthetics .
Molecular Weight: 284.3 · pKa: 8.3 · Solubility in Water: Very slightly soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Methohexitone (Na).
Pharmacokinetics
Distribution: Methohexitone (Na) has a volume of distribution is 1 l/kg. plasma protein binding is 73 %.
Elimination: it is metabolised via extensive by Liver, plasma half-life is 1.5-6hr.
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Indications
Methohexitone (Na) is primarily indicated in conditions like Induction of anaesthesia.
Contraindications
Dosage
Methohexitone (Na)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 85 mg | 85 mg | — | IV | Initial dose; It provieds about 5-7 minutes of anesthesia. |
| 30 mg | 30 mg | — | IV intermittent | Maintenance dose; on every 4-7 minutes. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Methohexitone (Na) in overdosage may give rise to further complications which include Gangrene , Thrombosis .
Methohexitone (Na) produces potentially life-threatening effects which include Bronchospasm , Cardiovascular collapse. Careful monitoring is needed with proper medical management.
Methohexitone (Na) is known to cause more or less tolerable side effects which are usually transient. These include Local pain.
Warnings / Precautions
Available Brands
None recorded.