Methionine
Also known as: DL-Methionine
Methionine is a naturally occuring amino acid. Chemically Methionine is 2-amino-4-methyl-mercaptobutyric acid. Methionine is essential constituent of diet. May be used as an antidote in severe poisoning due to Paracetamol where Methionine is thought to prevent liver demage by reducing the concentration of toxic metabolite . Natural sources of it include fish, meat, and vegetable proteins. Given orally it causes few side effects, principally nausea. Must not be given more than ten hours after the over dosage as it may then exacerbate liver demage. .
Primary Characteristics
Methionine is also known as DL-Methionine.
It is of Natural origin and belongs to Amino Acid.
It is classified in Liver Prot ective pharmacological group. It is also classified under Dermatological Products .
Molecular Weight: 149.2 · pKa: 2.28, 9.21 · Solubility in Water: 1 in 55 · Solubility in Alcohol: very slight · Non-proprietary name: Methionine.
Pharmacokinetics
None recorded.
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Indications
Methionine is primarily indicated in conditions like Amino acid deficiency, Diaper rash, Incontinence, Paracetamol overdosage, Paracetamol poisoning.
Contraindications
Methionine is contraindicated in conditions like Acidosis, Chronic liver disease, Schizophrenia.
Dosage
Methionine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 6.25 g | 6.25 g | — | PO | As Required |
| Paediatric Dosage (20kg) | ||||
| 0.05 g/kg | 0.05 g/kg | Every 4h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 0.05 g/kg | 0.05 g/kg | Every 4h | Oral | - |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Methionine produces potentially life-threatening effects which include Encephalopathy . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Methionine are Hypotension, Disorientation , Nausea, Vomiting, Fever, Metabolic acidosis.
Methionine is known to cause more or less tolerable side effects which are usually transient. These include Drowsiness, Irritability, Nausea, Vomiting .
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.17.9 — Cholagogues & hepatic preparations