Mesna
Also known as: Sodium 2-Mercapto-Ethanesulfonate
Mesna is a detoxifying agent. Mesna is used to protect bladder mucosa from the irritant effect of ifosfamide or cyclophosphamide (anticancer drugs), acts by combining with thier toxic metabolite acrolein but does not prevent thier other toxic effects. Chemically Mesna is identified as sodium 2-mercaptoethane sulfonate. It also has mucolytic properties. It also has a mucolytic activity. Mesna is available for oral and intravenous administration.
Primary Characteristics
Mesna is also known as Sodium 2-Mercapto-Ethanesulfonate.
It is of Synthetic origin and belongs to Mercaptoethane.
It is classified in Antidotes pharmacological group.
Molecular Weight: 164.2 · Solubility in Water: > 1 in 2.5 · Non-proprietary name: Mesna.
Pharmacokinetics
Absorption: Mesna has an oral bioavailability is 83% (±7%), pre-systemic (first-pass) metabolism accounts for 12.5% (±12.5%).
Distribution: Mesna has a volume of distribution is 0.65 l/kg.
Elimination: it is metabolised via Plasma, plasma half-life is 22 min, renal excretion is 32 %.
Advertisement
Indications
Mesna is primarily indicated in conditions like Cyclophosphamide induced hemorrhagic cystitis, Ifosfamide induced hemorrhagic cystitis, Prostate cancer.
Mesna is also indicated for secondary conditions like Cancer.
Contraindications
Mesna is contraindicated in conditions like Hypersensitivity.
Dosage
Mesna's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 240 mg/m2 | 240 mg/m2 | — | IV Inf | 100-112% by weight of Ifosamide, As Required |
| 1.723 g/sq.metre | 1.723 g/sq.metre | Every 6h | PO | 100-112% by weight of ifosamide |
| Paediatric Dosage (20kg) | ||||
| 300 mg/sq.meter | 300 mg/sq.meter | Every 8h | Intra Venous | 20%w/w of Ifosfamide Dose |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Mesna are Diarrhea, Convulsions , Headache, Tremor.
Mesna is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Bronchospasm, Cough , Diarrhea, Exhaustion , Headache, Hypotension , Joint pain, Limb pain, Tachycardia, Yellowing of teeth.
Warnings / Precautions
Interference in Pathology
Mesna may interfere in the diagnosis of False +ve test for Ketone bodies in Urine .
Available Brands
Storage Conditions
Drug Classification
- 1.4.2.11 — Miscellaneous