Mesalazine
Also known as: 5- Amino Salicylic Acid
Mesalazine is ingredient of sulphasalizine and Mesalazine is used in the treatment of ulcerative collitis. It can be given both by mouth as an enema.
Primary Characteristics
Mesalazine is also known as 5- Amino Salicylic Acid.
It is of Synthetic origin and belongs to Aminosalicylic Acid.
It belongs to Ulcerative Colitis remedies (GI) pharmacological group on the basis of mechanism of action and also classified in Antipeptic Ulcerant pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 153.1 · pKa: 2, 5.8, 12 · Solubility in Water: Very slightly soluble · Solubility in Alcohol: Soluble · Non-proprietary name: Mesalazine.
Pharmacokinetics
Absorption: Mesalazine has an oral bioavailability is 14% (±14%).
Distribution: Mesalazine has a plasma protein binding is 50 %.
Elimination: it is metabolised via Hepatic, plasma half-life is 40mins, renal excretion is 30-50 %.
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Indications
Mesalazine is primarily indicated in conditions like Crohn's disease, Ulcerative colitis.
Contraindications
Mesalazine is contraindicated in conditions like Hypersensitivity.
Dosage
Mesalazine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 800 mg | 800 mg | Every 8h | PO | |
| 1 g | 1 g | — | Rectal(enema) | |
| 1 g | 1 g | — | Rectal(Supostories) | |
| Paediatric Dosage (20kg) | ||||
| 10 mg/kg | 10 mg/kg | Every 8h | Maintanance ,To maximum of 500mg | |
| 20 mg/kg | 20 mg/kg | Every 8h | For acute attacks (maximum 1g) | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Mesalazine in overdosage may give rise to further complications which include Hepatitis , Bronchospasm , Bronchospasm , Nephrotic syndrome , Blood dyscrasias , blood dyscrasias.
Mesalazine produces potentially life-threatening effects which include Myocarditis , Pericarditis . Careful monitoring is needed with proper medical management.
Mesalazine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal discomfort, Alopecia, Chest pain, Diarrhea, Fever, Hair loss, Headache, Leukopenia, Nausea, Paresthesias, Rashes , Vomiting .
Warnings / Precautions
Interference in Pathology
Mesalazine may interfere in the diagnosis of Assay methods for Glucose, Bilirubin, Urobilinogen, Phenylketones, VMA and Urinary Proteins .
Available Brands
Storage Conditions
Drug Classification
- 1.17.4 — Anti-inflammtory drugs