Lymecycline

Drug #431

Bacteriostatic antibiotic with actions, adverse effects, and interactions similar to tetracycline.

Primary Characteristics

It is of Synthetic origin and belongs to Lysine (Tetracycline).

It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 602.6 · pK_a: 9.7, 7.7 · Solubility in Water: Very soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Lymecycline.

Pharmacokinetics

Absorption: Lymecycline has an oral bioavailability is 97% (±2%).

Distribution: Lymecycline has a plasma protein binding is 45 %.

Elimination: plasma half-life is 10.5 hr, renal excretion is 30 %.

Indications

Lymecycline is primarily indicated in conditions like Acne vulgaris, Amoebiasis, Bacterial infections, Brucellosis, Endocarditis, Ornithosis, Pneumonia, Psittacosis, Rickettsiae, Syphilis.

Lymecycline is also indicated for secondary conditions like Acute sinusitis, Chronic bronchitis, Helicobacter pylori infection, Soft tissue infections, Trachoma.

Contraindications

Lymecycline is contraindicated in conditions like Systemic lupus erythematosus.

Dosage

Lymecycline's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3.571 mg/kg	3.571 mg/kg	—	IV	As Required
408 mg	408 mg	Every 8h	PO	As recommended.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Lymecycline in overdosage may give rise to further complications which include Increased blood urea nitrogen , Azotemia, Hyperphosphatemia, Acidosis , Azotemia.

Lymecycline produces potentially life-threatening effects which include Anaphylaxis , Acute hepatic dysfunctioning. Careful monitoring is needed with proper medical management.

Lymecycline is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Enamel hypoplasia, Glossitis, Headache, Increased intracranial pressure, Nausea, Photosensitivity, Stomach pain, Stomatitis, Vaginitis.

Warnings / Precautions

Tetracyclines should only be used with caution in patients with hepatic dysfunction, lest accumulation occurs with increased toxicity. Careful monitoring of dosage by serum levels is necessary. High dosage of tetracyclines may be hepatotoxic and great care should be used with concurrent administration of other hepatotoxic drugs. Tetracyclines should only be administered with great caution in patients with renal insufficiency lest accumulation occurs with increased toxicity. Dosage may require reduction. High dosage of tetracyclines may be nephrotoxic.

Interference in Pathology

Lymecycline may interfere in the diagnosis of False Positive result of serum amylase in pregnant women , False Positive fluorescence in Hengerty Method for measuring Urinary Catecholamines .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

408 mg

Storage Conditions

Lymecycline should be stored Caps.

Drug Classification

1.6.2.2.3 — Tetracyclines

Manufacturers

Manufacturers of Lymecycline in Pakistan:

Atco Macter