Ketazolam
Ketazolam is a long acting benzodiazipine used as an anxiolytic. Ketazolam is prepared by chemical synthesis and possesses chiral carbon atom. Ketazolam is not available in any combination preparation. Ketazolam is administered orally.
Primary Characteristics
It is of Synthetic origin and belongs to Benzodiazepine.
It belongs to Chloride Channel Potentiater (GABA operated) pharmacological group on the basis of mechanism of action and also classified in Anxiolytics pharmacological group. It is also classified under Psychotherapeutic Drugs .
Molecular Weight: 368.8 · Solubility in Water: <1 in 1000 · Solubility in Alcohol: 1 in 100 · Non-proprietary name: Ketazolam.
Pharmacokinetics
Absorption: Ketazolam has an oral bioavailability is 50% (±50%).
Elimination: it is metabolised via Hepatic, plasma half-life is 1-5 hr.
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Indications
Ketazolam is primarily indicated in conditions like Anxiety, Cerebrovascular accident, Irritability, Multiple sclerosis, Spasticity, Spinal cord trauma, Tension.
Contraindications
Ketazolam is contraindicated in conditions like Phobias, Hypersensitivity, Chronic psychosis.
Dosage
Ketazolam's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 – 60 mg | — | Every 24h | PO | At bed time. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Ketazolam in overdosage may give rise to further complications which include Diarrhoea , Depression , Sedation , Hyperacusis , Rebound insomnia, Tension, Photophobia, Severe anxiety.
The signs and symptoms that are produced after acute overdosage of Ketazolam are Coma, Respiratory depression, Respiratory depression, Atonia , Respiratory depression.
Ketazolam is known to cause more or less tolerable side effects which are usually transient. These include Confusion, Drowsiness, Light headedness, Slurred speech, Tremor, Vertigo.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.24.3 — Drugs used in anxiety and sleep disorders