Isoproterenol
Also known as: Isoprenaline, Isopropylarterenol
Isoproterenol is used to prevent and treat wheezing,shortness of breath,chronic bronchitis and other lung diseases.<br>Isoproterenol (HCl) is a beta receptor agonist used in asthma by inhalation or orally. It may also be used as intravenous infusion in treatment of shock. More likely to cause cardiac arrhythmias than dopamine or dobutamine.<br>Isoproterenol (Sulphate) is a sympathomimetic, stimulates beta-adrenoceptors. It has a powerful stimulating action on the heart and increases cardiac output, excitability, and rate. It also stimulates CNS and exhibits bronchodilating properties.
Primary Characteristics
Isoproterenol is also known as Isoprenaline, Isopropylarterenol, Isoproterenol (HCl), Isoproterenol (Sulphate).
It is of Synthetic origin and belongs to Catecholamine.
It belongs to Beta adrenergic agonist pharmacological group on the basis of mechanism of action and also classified in Bronchodilator pharmacological group.
Molecular Weight: 211.3 · pKa: 8.64 · Solubility in Water: 1 in 3 · Solubility in Alcohol: 1 in 50 · Non-proprietary name: Isoproterenol.
Pharmacokinetics
Absorption: Isoproterenol has an oral bioavailability is 85% (±10%).
Distribution: Isoproterenol has a volume of distribution is 0.5 l/kg. plasma protein binding is 62-74%.
Elimination: it is metabolised via Liver and lungs, plasma half-life is 5 min (phase 1), > 2.5 hr (phase 2), renal excretion is 75 %.
Advertisement
Indications
Isoproterenol is primarily indicated in conditions like Acute bronchospasm, Asthma, Bradycardia, Bronchitis, Heart block, Reversible airways obstruction, Stokes-adams attack.
Contraindications
Isoproterenol is contraindicated in conditions like Cardiac arrhythmia, Diabetes mellitus, Myocardial infarction, Thyrotoxicosis, Ischaemic heart disease, Cystic fibrosis, Quadriplegia, Subvalvular aortic stenosis, Hypersensitivity.
Dosage
Isoproterenol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 6 ug/min | 6 ug/min | — | Stokes adams attacks. | |
| 2.5 ug/min | 2.5 ug/min | — | Infusion | Beadycardia |
| 0.005 mg/kg | 0.005 mg/kg | — | Inhalation | As Required |
| 40 ug | 40 ug | — | IV infusion | |
| 200 ug | 200 ug | — | S/C or IM | |
| Paediatric Dosage (20kg) | ||||
| 2.05 ug/kg.min | 2.05 ug/kg.min | — | IV Infusion | For Paeds of All Ages , As Required |
| Neonatal Dosage (3kg) | ||||
| 2.05 ug/kg.min | 2.05 ug/kg.min | — | IV Infusion | As required |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Isoproterenol in overdosage may give rise to further complications which include Cardiac arrhythmias, Cardiac arrhythmias , Dizziness , Cough , Nervousness , Tremors .
Isoproterenol produces potentially life-threatening effects which include Cardiac Arrest , Cardiac arrest, Ventilatory arrest. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Isoproterenol are Tachycardia , Tremor, Restlessness , Anxiety , B.P. alteration, Excitement.
Isoproterenol is known to cause more or less tolerable side effects which are usually transient. These include Anginal pain, Chest pain, damage to the teeth, Dizziness, Dryness of mouth, Flushing, Headache, Hypertension , Irregular heart beat, Nausea, Nervousness, Palpitation, Sleeplessness, Tachycardia, Tremor.
Warnings / Precautions
Available Brands
Click on a strength to view available brands.
Single Ingredient
Storage Conditions
Drug Classification
- 1.12.2 — Antiarrhythmic drugs
- 2.12.3.7 — Direct vasodilators
- 3.21.4.3 — Sympathomimetics
- 4.25.1.1 — Oral/Parenteral antiasthmatics
- 5.25.1.2 — Inhalants
Manufacturers
Manufacturers of Isoproterenol in Pakistan: