Ipratropium (Br)
Ipratropium (Br) is a quaternary derivative of atropine and a cholinergic blocking agent. It was the first muscarinic receptor blocking agent to acheive wide therapetic use in a pressurized aerosol. Ipratropium (Br) is prepared by chemical synthesis and the racemate is used clinically. It causes dialatation of bronchiol and is used to treat asthma and obstructive pulmonary disease. Ipratropium (Br) is available for inhalational administration.
Primary Characteristics
It is of Synthetic origin and belongs to Tropane Alkaloid.
It belongs to Cholinergic muscarinic antagonist pharmacological group on the basis of mechanism of action and also classified in Bronchodilator pharmacological group. It is also classified under Respiratory Inhalant Products .
Molecular Weight: 430.4 · Solubility in Water: soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Ipratropium (Br).
Pharmacokinetics
Elimination: renal excretion is Urine.
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Indications
Ipratropium (Br) is primarily indicated in conditions like Asthma, Bronchospasm prophylaxis, Chronic obstructive pulmonary disease, Reversible airways obstruction, Rhinorrhea.
Ipratropium (Br) is also indicated for secondary conditions like Rapid reversion to sinus ryhthm.
Contraindications
Ipratropium (Br) is contraindicated in conditions like Glucoma, Prostatic hypertrophy, Hypersensitivity, Urinary retention, Bladder obstruction.
Dosage
Ipratropium (Br)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 30 mcg | 30 mcg | Every 8h | Inhalation | Frequency may be increased upto 4 times/day if needed. |
| Paediatric Dosage (20kg) | ||||
| 250 ug | 250 ug | Every 6h | To total dose of 1mg for asthma). | |
| 20 ug | 20 ug | Every 8h | Inhalation | As Required. Reversible airways obstruction. |
| Neonatal Dosage (3kg) | ||||
| 12.5 ug/kg | 12.5 ug/kg | Every 8h | Inhalation | Via nebulizer |
Drug Interactions
None recorded.
Side Effects
Ipratropium (Br) in overdosage may give rise to further complications which include Tachycardia , Palpitation , Angina , Tremors , Arrythmia, Tachycardia.
The signs and symptoms that are produced after acute overdosage of Ipratropium (Br) are Palpitations , Increased heart rate.
Ipratropium (Br) is known to cause more or less tolerable side effects which are usually transient. These include Anaphylaxia, Backache , Blurred vision, Constipation , Dizziness, Dry mouth, Dyspepsia , Headache, Nasal congestion , Nasal irritation, Nausea and vomiting, Rashes , Urinary retention, Urinary RetentionX, Urticaria.
Warnings / Precautions
Available Brands
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Single Ingredient
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.25.1.2 — Inhalants