Iloprost
Iloprost is a vasodialator (expands the blood vessels) and platelet aggregation inhibitor.Iloprost is carbacyclin analog of prostaglandin I-2 in which the enolether oxygen of prostaglandin is replaced by a methylene group and the lower side chain is further modified in order to enhance the biological potency as well as the metabolic stability of the chemical. its metabolic half life is longer than that of prostaglandin I-2. Iloprost is effective in the treatment of peripheral vascular disease. There are no combination products that contain this drug Iloprost is a synthetic analogue of prostacylin.
Primary Characteristics
It is of Synthetic origin and belongs to Carbacyclin.
It is classified in Prostaglandin pharmacological group.
Molecular Weight: 360 · pKa: 4.7 · Solubility in Water: 1 in 1000-10000 · Solubility in Alcohol: soluble · Non-proprietary name: Iloprost.
Pharmacokinetics
Absorption: Iloprost has an oral bioavailability is 8% (±8%).
Distribution: Iloprost has a volume of distribution is 0.7-0.8 l/kg. plasma protein binding is 60%.
Elimination: it is metabolised via Hepatic, plasma half-life is 6 min, 30 min, renal excretion is 68%.
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Indications
Iloprost is primarily indicated in conditions like Buerger's disease, Peripheral arterial occlusive disease, Pulmonary hypertension, Raynaud's phenomenon.
Contraindications
Iloprost is contraindicated in conditions like Peptic ulcer, Trauma, Intracranial hemorrhage.
Dosage
Iloprost's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 – 8 ug | — | — | Inhalation | for 6 hours, For pulmonary hypertension . |
| 2.5 – 5 ug | — | — | Inhalation | 6-9 times daily according toresponeo. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Iloprost in overdosage may give rise to further complications which include Hypotension , Hypotension , Vasodilation , Vasovagal attacks , Chest pain .
The signs and symptoms that are produced after acute overdosage of Iloprost are Hypotension, Nausea & vomiting, Syncope , Facial flushing.
Iloprost is known to cause more or less tolerable side effects which are usually transient. These include Aching in the affective Limb, Bronchospasm, Cough , Diarrhea, Dizziness, Fatigue, Headache, Malaise, Nausea, Obstructive Arterial disease, Vomiting .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.10.2 — Anticoagulants/Platelet deaggregators
- 2.12.3.7 — Direct vasodilators