Hydroxychloroquine (Sulphate)
Hydroxychloroquine is a drug which is similar in its uses and actions to chloroquine phosphate. Hydroxychloroquine (Sulphate) is used to treat malaria, rheumatoid arthritis and lupus erythematosus.
Primary Characteristics
It is of Synthetic origin and belongs to Chloroquine.
It belongs to Antiplasmodial pharmacological group on the basis of mechanism of action and also classified in Antimalarial Agent pharmacological group.
Molecular Weight: 433.9 · Solubility in Water: 1 in 5 · Solubility in Alcohol: Insoluble · Non-proprietary name: Hydroxychloroquine (Sulphate).
Pharmacokinetics
Absorption: Hydroxychloroquine (Sulphate) has an oral bioavailability is 92.5% (±2.5%).
Distribution: Hydroxychloroquine (Sulphate) has a plasma protein binding is 55%.
Elimination: it is metabolised via 50% Hepatic, plasma half-life is 3 days(alpha phase) 18 days (beta phase), renal excretion is 50-60%.
Advertisement
Indications
Hydroxychloroquine (Sulphate) is primarily indicated in conditions like Adjunctive treatment of cortical myoclonus, Dermatological diseases, Discoid and systemic lupus erythematosus, Juvenile chronic arthritis, Malaria, Malaria prophylaxis, Premenstrual syndrome, Prophylaxis of bipolar disorder, Prostate cancer (metastatic), flare with initial gonadorelin therapy, Rheumatoid arthritis, Systemic and discoid lupus erythematosus.
Contraindications
Hydroxychloroquine (Sulphate) is contraindicated in conditions like Psoriasis, Renal diseases, Hepatic disease, Retinopathy, G6pd deficiency, GI diseases, Neurological disorders, Blood disorders, Porphyria cutanea tarda.
Dosage
Hydroxychloroquine (Sulphate)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 400 mg | 400 mg | Every 8h | PO | Maintenance, As Required |
| 800 mg | 800 mg | Every 6h | PO | Initially for Once |
| Paediatric Dosage (20kg) | ||||
| 5 mg/kg | 5 mg/kg | — | PO | Once weekly |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Hydroxychloroquine (Sulphate) in overdosage may give rise to further complications which include Retinotoxicity .
Hydroxychloroquine (Sulphate) produces potentially life-threatening effects which include Cardiotoxicity . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Hydroxychloroquine (Sulphate) are Death , Convulsions , Drowsiness, Drowsiness, Headache, Cardiopulmonary arrest, Cardiovascular collapse, Visual distrubances.
Hydroxychloroquine (Sulphate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Alopecia, Anorexia , Ataxia, Bleaching of hair, Diarrhea, Emotional upsets, Headache, Muscular weakness, Nausea, Nerve deafness, Nervousness, Nightmares, Psychosis, Skin reactions, Tinnitus, VertigoX, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.6.4.3 — Antimalarials