Fusidic Acid

Also known as: Sodium fusidate

Drug #331

Fusidic Acid is a steroid antibiotic. Fusidic Acid is used to treat the infection caused by penicillin resistant staphylococci.

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Primary Characteristics

Fusidic Acid is also known as Sodium fusidate.

It is of Semi Synthetic origin and belongs to Fusidane.

It belongs to Antibacterial (Proetin synthesis inhibitor) pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.

Molecular Weight: 525.7 · pK_a: 5.35 · Solubility in Water: 1 in 1 · Solubility in Alcohol: 1 in 5 · Non-proprietary name: Fusidic Acid.

Pharmacokinetics

Absorption: Fusidic Acid has an oral bioavailability is 50% (±50%).

Distribution: Fusidic Acid has a volume of distribution is 10.85±3.88 litre. plasma protein binding is 97%.

Elimination: it is metabolised via extensive by liver, plasma half-life is 8.7-9.4 hr, renal excretion is <1%.

Indications

Fusidic Acid is primarily indicated in conditions like Bone and joint infection, Cystic fibrosis, Endocarditis, Food allergy, Muscle relaxation (rapid onset, short duration), Osteomyelitis, Pneumonia, Septicaemia, Skin infections, Small cell carcinoma, Soft tissue infections.

Contraindications

Fusidic Acid is contraindicated in conditions like Hepatic failure, Hypersensitivity.

Dosage

Fusidic Acid's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.5 mg	0.5 mg	Every 12h	Ophthalmic	-
1 %	1 %	Every 6h	Ophthalmic	drops.
500 mg	500 mg	Every 8h	PO, IV
2 %	2 %	Every 8h	Topical	-
Paediatric Dosage (20kg)
1 %	1 %	Every 12h	Opthalmic	For Paeds of all ages
25 mg/kg	25 mg/kg	Every 8h	Oral	-
6.5 mg/kg	6.5 mg/kg	Every 8h	Slow IV	Over 6 Hours
Neonatal Dosage (3kg)
12.5 mg/kg	12.5 mg/kg	Every 8h	Oral
6.5 mg/kg	6.5 mg/kg	—	Slow Intravenous

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fusidic Acid in overdosage may give rise to further complications which include Jaundice , Jaundice , Cholestasis , Hemolysis , Hyperbilirubinemia.

Fusidic Acid is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Epigastric pain, GI symptoms, Pruritus , Rashes , Vomiting .

Warnings / Precautions

Use of topical preparation near the eyes should be avoided because of potential conjunctival irritation. Parentrally the drug should be infused slowly to decrease to decrease the incidence of thrombophlebitis and vasospam. Oral administration should be instituted as soon as possible. Long term topical theorapy should beavoided particularly is infants & children.

Interference in Pathology

Fusidic Acid may interfere in the diagnosis of Measurement of Bile Acids in serum by enzymatic assay , Fluoromet ric Tests for cortisol in urine and plasma .

Available Brands

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Single Ingredient

Cream

Eye Drops

Eye Oint

Inf

Oint

Susp

Tabs

Multi-Ingredient Combinations

Cream

2 %w/w 20 mg

Storage Conditions

Fusidic Acid should be stored Eye Oint.

Drug Classification

1.6.2.2.13 — Others
2.13.2.1 — Antibacterials, topical
3.21.1.1 — Antibacterials

Manufacturers

Manufacturers of Fusidic Acid in Pakistan: