Foscarnet (Na)

Also known as: Phosphonatoformate Trisodium

Drug #326

Foscarnet (Na) is antiviral agent, is an inorganic pyrophosphate compound. Foscarnet (Na) is active against herpes simplex virus, vericella zoster virus, cytomegalovirus, and HIV. Foscarnet (Na) is approved for the treatment of cytomegalic retinitis in immuno compromised HIV patient, especially if the infection is resistant to ganciclovir.

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Primary Characteristics

Foscarnet (Na) is also known as Phosphonatoformate Trisodium.

It is of Synthetic origin and belongs to Phosphonformate.

It belongs to DNA polymerase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Antiviral Agents .

Molecular Weight: 300 · pK_a: 7.27 · Solubility in Water: 1 in 2 · Solubility in Alcohol: <1 in 100,000 · Non-proprietary name: Foscarnet (Na).

Pharmacokinetics

Absorption: Foscarnet (Na) has an oral bioavailability is 20%, pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).

Distribution: Foscarnet (Na) has a volume of distribution is 0.5 l/kg. plasma protein binding is 15.5%.

Elimination: it is metabolised via Insignificant, plasma half-life is 15 hr, renal excretion is 80-97%.

Indications

Foscarnet (Na) is primarily indicated in conditions like Cytomegalovirus infections, Cytomegalovirus retinitis in aids patients, Herpes simplex infections, HIV infection, Mucocutaneous herpes simplex infection, Viral infection.

Contraindications

Foscarnet (Na) is contraindicated in conditions like Renal diseases, Pregnancy, Breast feeding.

Dosage

Foscarnet (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.66 mg/kg.min	0.66 mg/kg.min	—	IV Inf	For 30 Minutes, Followed by Maint. As Required
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown6 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Foscarnet (Na) in overdosage may give rise to further complications which include Headache , Thrombophlebitis .

Foscarnet (Na) produces potentially life-threatening effects which include Nephrotoxicity, Acute Renal Failure , Bilateral loin pain, Tenderness, Prophylactic hydration. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Foscarnet (Na) are Hallucinations , Anxiety , Irritability.

Foscarnet (Na) is known to cause more or less tolerable side effects which are usually transient. These include Headache, Thrombophlebitis .

Warnings / Precautions

Foscarnet should be used with caution in patients with any pre-existing liver disease, kidney disease, heart disease, history of seizure disorder or any allergies. This medication should be used only if clearly needed during pregnancy.

Interference in Pathology

Foscarnet (Na) may interfere in the diagnosis of Elevation in ALT or AST.

Available Brands

None recorded.

Storage Conditions

Foscarnet (Na) should be stored IV inf.

Drug Classification

1.6.5.1 — Herpes and cytomegalovirus infection