Fluoride

Drug #314

Fluoride is used to prevent dental caries in areas where the supply of drinking water contains low amounts of it (less than 0.7 ppm).

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Primary Characteristics

It is of Synthetic origin and belongs to Sodium Fluoride.

It belongs to Minerals and Electrolytes pharmacological group on the basis of mechanism of action and also classified in Electrolyte Oral pharmacological group.

Molecular Weight: 42 · pK_a: not relevant · Solubility in Water: 1 in 25 · Solubility in Alcohol: virtually insoluble · Non-proprietary name: Fluoride.

Pharmacokinetics

Absorption: Fluoride has an oral bioavailability is 82.5% (±2.5%).

Distribution: Fluoride has a volume of distribution is high.

Elimination: plasma half-life is short, renal excretion is major.

Indications

Fluoride is primarily indicated in conditions like Dental caries, Prophylaxis of dental carries.

Contraindications

None recorded.

Dosage

Fluoride's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.05 %	0.05 %	Every 24h	Buccal	As Required
Paediatric Dosage (20kg)
0.05 mg/kg	0.05 mg/kg	Every 24h	Buccal	-
Neonatal Dosage (3kg)
0.046 mg/kg	0.046 mg/kg	Every 24h	Oral

Drug Interactions

Unknown2 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fluoride in overdosage may give rise to further complications which include Exostosis, Osteosclerosis .

The signs and symptoms that are produced after acute overdosage of Fluoride are Diarrhea, Death , Convulsions , Abdominal pain, Respiratory failure, Paresthesia, Nausea & vomiting, CNS irritation, Hyperactive reflexes, Positive Chvostek's sign, Cardiac failure.

Fluoride is known to cause more or less tolerable side effects which are usually transient. These include Chalky enamel, Mottled dental enamel.

Warnings / Precautions

Infrequent nausea occur when fluoride is taken in an empty stomach, it may be reduced by taking it with or after meal. Consult physician before using fluoride during pregnancy or lactation.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Caps

0.2 mg

Storage Conditions

Fluoride should be stored Tab, Drops.

Drug Classification

1.17.8 — Stomatologicals and dentifrices

Manufacturers

Manufacturers of Fluoride in Pakistan:

Geofman Impex