DrugInfoSys

Fluorescein

Drug #313

Fluorescein is a staining agent. Fluorescein is used as a test of pancreatc function and for the detection of damage to cornea.

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Primary Characteristics

Fluorescein is also known as Fluorescein Sodium.

It is of Synthetic origin and belongs to Isobenzofuran.

It belongs to Fluorescent Dye pharmacological group on the basis of mechanism of action. It is also classified under Diagnostic Aids .

Molecular Weight: 376.3 · Solubility in Water: soluble · Solubility in Alcohol: slightly soluble · Non-proprietary name: Fluorescein · pH: 8.7 · Isotonic value: 3.34.

Molecular structure of Fluorescein

Pharmacokinetics

Distribution: Fluorescein has a plasma protein binding is 85%.

Elimination: it is metabolised via Hepatic, plasma half-life is <1 hr, renal excretion is major.

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Indications

Fluorescein is primarily indicated in conditions like Opthalmology, Water replacement.

Fluorescein is also indicated for secondary conditions like Corneal ulcers.

Contraindications

Fluorescein is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Fluorescein's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
1 %1 %—OphthalmicAs Required
Paediatric Dosage (20kg)
0.125 %0.125 %—Opthalmic As Required
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Fluorescein is known to cause more or less tolerable side effects which are usually transient. These include Convulsions , Gastrointestinal disturbances, Headache, Hypersensitivity , Hypotension , Intense pain at sites of application, Nausea and vomiting, Syncope .

Warnings / Precautions

Care must be taken to avoid extravasation during injection as the high pH of fluorescein solution can result in severe local tissue damage.Complications resulting from extravasation can cause severe pain in the arm for up to several hours. Caution is to be exercised in patients with a history of allergy or bronchial asthma. An emergency tray should be available in the event of possible reaction to FLUORESCITE Injection 10%. Use only if the container is undamaged.

Interference in Pathology

Fluorescein may interfere in the diagnosis of Urinary Tests of Urobilin by producing orange-yello discoloration of urine .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Eye Drops
0.6 mg2 %w/v
Eye Drops
1 %w/v

Storage Conditions

Fluorescein should be stored Eye Drops, Inj.

Drug Classification

  1. 1.14.1 — Ophthalmic drugs

Manufacturers

Manufacturers of Fluorescein in Pakistan:

NovartisOphth-Pharma