Flecainide (Acetate)

Also known as: Apocard E-0735, Tambocor

Drug #306

Flecainide (Acetate) fluorinated benzamine. Flecainide (Acetate) is a potent sodium channel and potassium channel blocking agent. Flecainide (Acetate) maintains normal heart rate and is used to treat irregular heart rhythms (arrhythmias).

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Primary Characteristics

Flecainide (Acetate) is also known as Apocard E-0735, Tambocor.

It is of Synthetic origin and belongs to Piperidylbenzamide.

It belongs to Na-Channel Antiarrhythmic antagonist pharmacological group on the basis of mechanism of action and also classified in Anti arrhythmic agents pharmacological group.

Molecular Weight: 474.4 · pK_a: 9.3 · Solubility in Alcohol: 1 in 3.3 · Non-proprietary name: Flecainide (Acetate) · pH: 4.

Molecular structure of Flecainide (Acetate)

Pharmacokinetics

Absorption: Flecainide (Acetate) has an oral bioavailability is 95% (±5%), pre-systemic (first-pass) metabolism accounts for 0.5% (±0.5%).

Distribution: Flecainide (Acetate) has a volume of distribution is 9.5 l/kg. plasma protein binding is 40%.

Elimination: it is metabolised via extensive by Liver, by wrine, plasma half-life is 14 hr, renal excretion is largely.

Indications

Flecainide (Acetate) is primarily indicated in conditions like Atrial fibrillation, Atrial flutter, Cardiac arrhythmia, Ventricular arrhythmias, Ventricular fibrillation.

Flecainide (Acetate) is also indicated for secondary conditions like Angina, Blood Pressure.

Contraindications

Flecainide (Acetate) is contraindicated in conditions like Cardiogenic shock, Cardiac failure, Conduction system disease.

Dosage

Flecainide (Acetate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0 – 2 mg/kg	—	Every 0.8h	IV inf
0 – 2 mg/kg	—	Every 2.4h	IV inj
1.785 mg/kg	1.785 mg/kg	Every 12h	PO	Individed doses for supra ventricular tachycardia & at rial fibrillation
Paediatric Dosage (20kg)
100 – 400 mg	—	Every 12h	PO
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown7 interactions

4 interactions

Major1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Flecainide (Acetate) produces potentially life-threatening effects which include Conduction system disorders, Heart failure, Ventricular proarrhythmic effects. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Flecainide (Acetate) are Asystole, Respiratory paralysis.

Flecainide (Acetate) is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Ataxia, Blurred vision, Headache, Light-headedness, Metallic taste, Nausea.

Warnings / Precautions

Patients with pacemakers (especially those who may be pacemaker dependent because stimulation threshold may rise appreciably); avoid in sinus node dysfunction, atrial conduction defects, second-degree or greater AV block, bundle branch block or distal block unless pacing rescue available; atrial fibrillation following heart surgery; elderly (accumulation may occur); hepatic impairment; renal impairment (monitor plasma-flecainide concentration); pregnancy; breast-feeding.

Available Brands

None recorded.

Storage Conditions

Flecainide (Acetate) should be stored Tab.

Drug Classification

1.12.2 — Antiarrhythmic drugs