DrugInfoSys

Dydrogesterone

Also known as: Isopregnenone, Dehydroprogesterone

Drug #270

Dydrogesterone used in the treatment of menstrual disorders such as endometriosis.

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Primary Characteristics

Dydrogesterone is also known as Isopregnenone, Dehydroprogesterone.

It is of Synthetic origin and belongs to Progestogen.

It belongs to Progesterone agonist pharmacological group on the basis of mechanism of action and also classified in Female Sex Hormones pharmacological group. It is also classified under Sex Hormones .

Molecular Weight: 312.4 · Solubility in Water: practically insoluble · Solubility in Alcohol: 1 in 40 · Non-proprietary name: Dydrogesterone.

Molecular structure of Dydrogesterone

Pharmacokinetics

Distribution: Dydrogesterone has a plasma protein binding is 97%.

Elimination: plasma half-life is 6 hr, renal excretion is > 60%.

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Indications

Dydrogesterone is primarily indicated in conditions like Amenorrhoea, Dysfunctional uterine bleeding, Dysmenorrhoea, Endometriosis, Habitual abortion, Infertility, Infertility or irregular cycles, Premenstural syndrome.

Dydrogesterone is also indicated for secondary conditions like Premenstrual syndrome, Recurrent miscarriage (habitual abortion).

Contraindications

None recorded.

Dosage

Dydrogesterone's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
6.5 mg6.5 mgEvery 8hPOFor endometriosis.
10 mg10 mgEvery 12hPO
Paediatric Dosage (20kg)
0 – 0——Not applicable in this age group
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dydrogesterone is known to cause more or less tolerable side effects which are usually transient. These include Acne, Allergic, Appetite and weight changes, Breakthrough bleeding, Breast discomfort, Chloasma , dizziness, Edema, Fluid retention, Gynecomastia, Hair loss, Mental depression, Nausea, Skin rashes, Urticaria.

Warnings / Precautions

Dydrogesterone should be used with caution in patients with cardiovascular or renal impairment, diabetes mellitus, asthma, epilepsy and migraine, history of mental depression, undiagnosed vaginal bleeding, liver impairment. It is not recommended to take it in early pregnancy.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps
10 mg
Tabs
10 mg

Multi-Ingredient Combinations

Tabs
10 mg

Storage Conditions

Dydrogesterone should be stored Tab.

Drug Classification

  1. 1.18.5 — Progestogens

Manufacturers

Manufacturers of Dydrogesterone in Pakistan:

AbbottHI-WARBLEHighnoonPharmixSamiZafa