Diloxanide (Furoate)

Drug #244

Diloxanide (Furoate) is a dichloroacetamide derivative. It acts as amebicidal agent. Diloxanide (Furoate) is used in the treatment of intestinal amebiasis (dysentery) in combination with other drugs. Diloxanide fucoate is a pcodeng and is hydcolyned in the gut to diloxamide (active ingredient)

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Primary Characteristics

It is of Synthetic origin and belongs to Anilide.

It is classified in Anthelmintics pharmacological group.

Molecular Weight: 328.2 · Solubility in Water: very slight · Solubility in Alcohol: 1 in 100 · Non-proprietary name: Diloxanide (Furoate).

Molecular structure of Diloxanide (Furoate)

Pharmacokinetics

Absorption: Diloxanide (Furoate) has an pre-systemic (first-pass) metabolism accounts for 92.5% (±2.5%).

Elimination: it is metabolised via via Intestine, plasma half-life is short 3 hour, renal excretion is rapid.

Indications

Diloxanide (Furoate) is primarily indicated in conditions like Asymptomatic cyst passers, Eradication, Intestinal amoebiasis, Mild amebic dysentery, Non-dysenteric intestinal amebiasis, Oliguria due to renal failure, Oliguria due to renal failure, Parkinsonism.

Contraindications

None recorded.

Dosage

Diloxanide (Furoate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
20 – 25 mg/kg	—	—		May repeat if needed take with food.
500 mg	500 mg	Every 8h	PO	For 10 Days
Paediatric Dosage (20kg)
7.5 mg/kg	7.5 mg/kg	Every 8h	Oral	Recommended for 5-12 Yrs of Children
20 mg/kg	20 mg/kg	—	Oral	Children of 12 years. It is given for 10days.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Diloxanide (Furoate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Albuminuria , Anorexia , Diarrhea, Esophagitis, Flatulence, Nausea, Paresthesias, Urticaria, Vomiting .

Warnings / Precautions

Diloxanide should be used with caution in patient with symptomatic intestinal amebiasis or extra-intestinal amebiasis, during pregnancy and in childrens less than 2 years of age.

Interference in Pathology

Diloxanide (Furoate) may interfere in the diagnosis of Fecal examination.

Available Brands

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Single Ingredient

Susp

250 mg

Multi-Ingredient Combinations

Susp

100 mg/5ml 125 mg/5ml 250 mg 250 mg/5ml 500 mg/5ml

Tabs

125 mg 250 mg 400 mg 500 mg

Storage Conditions

Diloxanide (Furoate) should be stored Tab.

Drug Classification

1.6.4.1 — Antiamebic & antigiardiasis drugs

Manufacturers

Manufacturers of Diloxanide (Furoate) in Pakistan: