cabazitaxel

Drug #2343

Cabazitaxel is a type of taxane chemotherapy drug. The taxanes were originally developed from the yew tree. Cabazitaxel is also called Jevtana. It is a treatment for advanced prostate cancer for men who have had hormone treatment and docetaxel chemotherapy treatments that are no longer working

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Primary Characteristics

It belongs to natural taxoid 10-deacetylbaccatin III.

Molecular Weight: 835.93 · Non-proprietary name: cabazitaxel.

Pharmacokinetics

Distribution: cabazitaxel has a volume of distribution is 4,864 L. plasma protein binding is 92%.

Elimination: it is metabolised via liver (>95%),.

Indications

cabazitaxel is primarily indicated in conditions like Prostate cancer.

Contraindications

None recorded.

Dosage

None recorded.

Drug Interactions

None recorded.

Side Effects

The signs and symptoms that are produced after acute overdosage of cabazitaxel are Flushing, Nausea, Diarrhea, fatigue, swelling of the vien, Rashes , Allergic skin reactions.

Warnings / Precautions

Before starting cabazitaxel treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this. Do not receive any kind of immunization or vaccination without your doctor’s approval while taking cabazitaxel. You should refrain from taking St.John's Wort. Avoid drinking grapefruit juice or eating grapefruit. Currently, cabazitaxel is approved for the treatment of castrate resistant metastatic prostate cancer only (male population). However, there are no well-controlled studies regarding cabazitaxel use in pregnant women. Cabazitaxel may cause fetal harm if administered during pregnancy. Pregnant women should avoid exposure to cabazitaxel. For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking cabazitaxel. Barrier methods of contraception, such as condoms, are recommended.

Available Brands

None recorded.