Simeprevir
Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated for the treatment of chronic hepatitis C (CHC) infection as a component of a combination antiviral treatment regimen.The chemical name for simeprevir is (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2[[2-(4-isopropyl-1,3-thiazol-2-yl)-7-methoxy-8-methyl-4-quinolinyl]oxy]-5methyl 4,14 dioxo2,3,3a,4,5,6,7,8,9,11a,12,13,14,14atetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide.
Primary Characteristics
It is of Synthetic origin.
It belongs to Protease Inhibitor pharmacological group on the basis of mechanism of action.
Molecular Weight: 749.94 · Solubility in Water: insoluble · Non-proprietary name: Simeprevir.
Pharmacokinetics
Distribution: Simeprevir has a plasma protein binding is >99.9%.
Elimination: it is metabolised via hepatic, plasma half-life is 41 hrs, renal excretion is 91% by feces.less than 1% by urine.
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Indications
Simeprevir is primarily indicated in conditions like Chronic hepatitis C.
Contraindications
None recorded.
Dosage
Simeprevir's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 150 mg | 150 mg | — | PO | should be administered with both peginterferon alfa and ribavirin and food. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
None recorded.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.8.1 — Immunomodulators