conjugated Estrogens/Bazedoxifene

Drug #2323

Conjugated estrogens are purified from pregnant mares' urine and consist of the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares' urine. Conjugated estrogens are a mixture of sodium estrone sulfate and sodium equilin sulfate, and also contain as concomitant components, sodium sulfate conjugates, 17a-dihydroequilin, 17a-estradiol, and 17ß-dihydroequilin. Bazedoxifene is supplied as the acetate salt (bazedoxifene acetate) and has the chemical name 1H-Indol-5-ol,1-[[4-[2-(hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, monoacetate.it is used for the treatment of moderate to severe vasomotor symtoms and perventation of postmenopausal osteoporosis

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to sulfated steroids.

Molecular Weight: 372.41 · Non-proprietary name: conjugated Estrogens/Bazedoxifene.

Molecular structure of conjugated Estrogens/Bazedoxifene

Pharmacokinetics

Distribution: conjugated Estrogens/Bazedoxifene has a volume of distribution is 14.7 ± 3.9 L/kg. plasma protein binding is 90%.

Elimination: it is metabolised via hepatic, plasma half-life is 7.4hrs, renal excretion is urine.

Indications

conjugated Estrogens/Bazedoxifene is primarily indicated in conditions like Menopausal symptoms, Postmenopausal osteoporosis.

Contraindications

None recorded.

Dosage

conjugated Estrogens/Bazedoxifene's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
20 mg	20 mg	—	PO	Treatment of Moderate to Severe Vasomotor Symptoms Associated with Menopause
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

8 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

conjugated Estrogens/Bazedoxifene is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Dizziness, dyspepsia, muscle spasm, Nausea, Neck pain, oropharyngeal pain.

Warnings / Precautions

Women taking conjugated estrogen /bazedoxifen should not take progestins, additional estrogens or additional estrogen agonist/antagonists. Cardiovascular disorders, including venous thromboembolism, pulmonary embolism, stroke, and retinal vascular thrombosis. Malignant neoplasms, including endometrial cancer, breast cancer, and ovarian cancer. Estrogens increase the risk of gallbladder disease Discontinue estrogen if loss of vision, severe hypertriglyceridemia or cholestatic jaundice occur. Monitor thyroid function in women on thyroid replacement therapy .

Available Brands

None recorded.

Storage Conditions

conjugated Estrogens/Bazedoxifene should be stored tablet.

Drug Classification

1.18.4 — Estrogens, their combinations and related preparations