Vortioxetine
Vortioxetine HBr is an antidepressant agent, indicated for the treatment of Major Depressive Disorder. Vortioxetine HBr is known chemically as 1-[2-(2,4-Dimethyl-phenylsulfanyl) phenyl]-piperazine, hydrobromide.
Primary Characteristics
It is of Synthetic origin.
It belongs to Seletive Serotonin Reuptake Inhibitor pharmacological group on the basis of mechanism of action.
Molecular Weight: 397.36 · Solubility in Water: slightly soluble · Non-proprietary name: Vortioxetine.
Pharmacokinetics
Absorption: Vortioxetine has an oral bioavailability is 75%.
Distribution: Vortioxetine has a volume of distribution is 2600L. plasma protein binding is 98%.
Elimination: it is metabolised via hepatic, plasma half-life is 66hrs, renal excretion is by urine & feces.
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Indications
Vortioxetine is primarily indicated in conditions like Major Depressive Disorder.
Contraindications
None recorded.
Dosage
Vortioxetine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0 – 5 mg | — | — | PO | for patients who do not tolerate higher doses. |
| 0 – 10 mg | — | — | PO | known CYP2D6 poor metabolizers |
| 15 mg | 15 mg | — | PO | for major depressive disorder |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Vortioxetine is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Nausea, Vomiting .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.24.2.1 — Drugs used in depression