Dapoxetine HCl

Drug #2319

Dapoxetine hydrochloride is a selective serotonin reuptake inhibitors (SSRIs). It belongs to the pharmacotherapeutic group of other urologicals. the chemical name of Dapoxetine is ((+)-(S)-N,N-dimethyl-(a)-[2(1naphthalenyloxy)ethyl]-benzenemethanamine hydrochloride). It is the first compound specifically developed for the treatment of Premature ejaculation (PE).

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Primary Characteristics

It is of Synthetic origin and belongs to naphthalenes.

It belongs to Seletive Serotonin Reuptake Inhibitor pharmacological group on the basis of mechanism of action.

Molecular Weight: 341.88 · Solubility in Alcohol: soluble · Non-proprietary name: Dapoxetine HCl.

Pharmacokinetics

Absorption: Dapoxetine HCl has an oral bioavailability is 45% (±30%).

Distribution: Dapoxetine HCl has a volume of distribution is 162L. plasma protein binding is greater than 99%.

Elimination: it is metabolised via liver & kidney, plasma half-life is 1-2 hrs, renal excretion is by urine.

Indications

Dapoxetine HCl is primarily indicated in conditions like Premature ejaculation.

Contraindications

None recorded.

Dosage

Dapoxetine HCl's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
45 mg	45 mg	—	PO	approximately 1 to 3 hours prior to sexual activity.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dapoxetine HCl is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Anxiety, Dizziness, Fatigue, Headache, Insomnia, Libido, Nausea, Orthostatic hypotension, Restlessness, Syncope , Vomiting .

Warnings / Precautions

avoid to use with recreational drugs, Ethanol, Orthostatic hypotension, sucidal thought,syncope, Patient with cardiovascular risk factor, potent CYP2D6 inhibitors,mania, seizure, depression, psychotic disorder, hemorrhage, severe renal impariement, eye disorder, lactose intolrance, caution will be taken in all these situations.

Available Brands

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Single Ingredient

Tabs

60 mg

Storage Conditions

Dapoxetine HCl should be stored tablet.

Drug Classification

1.29 — Drugs used in renal, bladder, and prostatic disorders

Manufacturers

Manufacturers of Dapoxetine HCl in Pakistan:

Mark