Sultamicillin

Also known as:

Drug #2318

Sultamicillin is a double ester in which ampicillin and the beta-lactamase inhibitor sulbactam are linked via a methylene group. Chemically sultamicillin is the oxymethylpenicillinate sulphone ester of ampicillin.Sultamicillin is indicated for infections caused by susceptible micro-organisms. Typical indications are upper respiratory tract infections including sinusitis, otitis media and tonsillitis; lower respiratory tract infections including bacterial pneumonias and bronchitis; urinary tract infections and pyelonephritis; skin and soft tissue infections;intra-abdominal infections and gonococcal infections.

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Primary Characteristics

Sultamicillin is also known as .

It is of Synthetic origin.

It belongs to Beta Lactamase Inhibitor pharmacological group on the basis of mechanism of action.

Molecular Weight: 594.7 · Solubility in Water: soluble · Non-proprietary name: Sultamicillin.

Pharmacokinetics

Absorption: Sultamicillin has an oral bioavailability is 80%.

Elimination: plasma half-life is 0.75-1 hr, renal excretion is 50-75% in urine.

Indications

Sultamicillin is primarily indicated in conditions like Bronchitis, Gonococcal infections, Intra-abdominal infections, Otitis media, Pneumonia, Pyelonephritis, Sinusitis, Soft tissue and skin infections, Tonsillitis, Urinary tract infection.

Contraindications

None recorded.

Dosage

Sultamicillin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2.25 mg	2.25 mg	—	PO	In the treatment of uncomplicated gonorrhoea
562.5 mg	562.5 mg	—	PO
Paediatric Dosage (20kg)
25 – 50 mg	—	—	PO	The dosage for most infections in children weighing less than 30 kg
Neonatal Dosage (3kg)
No data.

Drug Interactions

9 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sultamicillin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anaphylactoid reactions, Angioedema, Dermatitis, Diarrhea, Dizziness, dyspepsia, Dyspnea, Enterocolitis , Fatigue, Headache, Hypersensitivity , Malaise, melaena, Nausea, Pruritis, Pseudomembranous colitis , Rash, Sedation , Somnolence , Urticaria, Vomiting .

Warnings / Precautions

anaphylactic reactions, Hepatotoxicity, clostridium difficile associated diarrhea, Patients with rare hereditary problems of galactose intolerance, Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency, all these situation require caution when used sultamicillin

Interference in Pathology

Sultamicillin may interfere in the diagnosis of False positive glycosuria.

Available Brands

None recorded.

Storage Conditions

Sultamicillin should be stored Tablet. Powder for Oral Suspension.

Drug Classification

1.6.2.1.1 — Penicillins