Diamorphine (HCl)

Also known as: Diacetylmorphine HCl

Drug #229

Diamorphine (HCl) is a narcotic analgesic (reliefes the pian with unconsciousness). It relieves moderate to severe pain. It produces feeling of well being.

← Previous drug Next drug →

Primary Characteristics

Diamorphine (HCl) is also known as Diacetylmorphine HCl.

It is of Semi Synthetic origin and belongs to Opioid.

It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action and also classified in Analgesic-Narcotic pharmacological group. It is also classified under Analgesics and Anti-inflammatory Agents .

Molecular Weight: 423.9 · pK_a: 7.6 · Solubility in Water: 1 in 1.6 · Solubility in Alcohol: 1 in 12 · Non-proprietary name: Diamorphine (HCl).

Molecular structure of Diamorphine (HCl)

Pharmacokinetics

Absorption: Diamorphine (HCl) has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 100%.

Distribution: Diamorphine (HCl) has a volume of distribution is 40-50 litre. plasma protein binding is not relevant.

Elimination: it is metabolised via complete (hepatic, Renal, Blood), plasma half-life is 1.7-5.3 hr, renal excretion is entire.

Indications

Diamorphine (HCl) is primarily indicated in conditions like Chronic pain, Cough, Opioid agonist dependence, Severe acute pain.

Contraindications

Diamorphine (HCl) is contraindicated in conditions like Respiratory disease, Biliary colic, Raised intracranial pressure, Head injury.

Dosage

Diamorphine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5 – 10 mg	—	Every 4h	IM	( For Acute pain & chronic pain)
5 mg	5 mg	—	IV	for pain of myocardial infarction at rate of 1 mg/min. 2.5-5mg can be given more if required.
0.107 mg/kg	0.107 mg/kg	Every 4h	SC	-
Paediatric Dosage (20kg)
0.075 mg/kg	0.075 mg/kg	Every 4h	Intra Muscular	-
100 – 75 ug/kg	—	Every 4h	IV infusion	1 to 12 year
12.5 – 25 ug/kg /hr	—	—	IV inj	1 month to 12 year
100 – 200 mg/kg	—	Every 4h	PO
0.075 mg/kg	0.075 mg/kg	Every 4h	Subcutaneous	-
Neonatal Dosage (3kg)
0.075 mg/kg	0.075 mg/kg	Every 4h	Intra Muscular	-
0.075 mg/kg	0.075 mg/kg	Every 4h	Subcutaneous	-

Drug Interactions

Unknown2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Diamorphine (HCl) in overdosage may give rise to further complications which include Nephrotic syndrome , Pulmonary edema, Thrombocytopenic purpura , Renal amyloidosis , Rhabdomyolysis , Reduced GFR (glomerular filtration rate), Decrease in sexual desire .

The signs and symptoms that are produced after acute overdosage of Diamorphine (HCl) are Nausea, Vomiting, Pulmonary edema , ECG alterations, Confusion , Respiratory depression, Hypothermia, Miosis, Respiratory depression, Dysphoria , Sedation , Respiratory failure, Sinus tachycardia, Rhabdomyolysis , Respiratory depression.

Diamorphine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Calmness , Constipation , Dependence , Dry mouth, Euphoria, Hypertension , Hypothermia , Mental clouding, Miosis , Nausea, Pruritus , Respiratory depression, Sedation , Spasm of the sphinctor of oddi, SweatingX, Vomiting .

Warnings / Precautions

The long term administration of diamorphine will result in physical dependence and therefore an obstinence syndrome will occur if diamorphine therapy is abruptly discontinued. Therefore gradually reduces the dosage regimen to prevent the obstinence syndrome. The dose and dosing interval of diamorphine must be titrated against the individual patient reports of their pain.

Interference in Pathology

Diamorphine (HCl) may interfere in the diagnosis of Interfere with the quantification of morphine by radioimmunoassay. .

Available Brands

None recorded.

Storage Conditions

Diamorphine (HCl) should be stored Inj.

Drug Classification

1.2.2 — Opioid analgesics