Dextropropoxyphene
Dextropropoxyphene is a weak narcotic anagesic (reliefes the pian with unconsciousness) and used in the management of moderate pain. Commonly Dextropropoxyphene is given in combination with paracetamol.
Primary Characteristics
It is of Synthetic origin and belongs to Opioid.
It belongs to OPIATE agonist pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 375.9 · pKa: 6.3 · Solubility in Water: 1 in 0.3 · Solubility in Alcohol: 1 in 1.5 · Non-proprietary name: Dextropropoxyphene.
Pharmacokinetics
Absorption: Dextropropoxyphene has an oral bioavailability is 97% (±2%), pre-systemic (first-pass) metabolism accounts for 60%.
Distribution: Dextropropoxyphene has a volume of distribution is ~16 l/kg. plasma protein binding is 70-80%.
Elimination: it is metabolised via extensive by liver, plasma half-life is 15 hr, renal excretion is 1%(unchanged) 13%(metabolite).
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Indications
Dextropropoxyphene is primarily indicated in conditions like Mild to moderate pain, Opioid addiction.
Contraindications
Dextropropoxyphene is contraindicated in conditions like Psychosis, Hypersensitivity.
Dosage
Dextropropoxyphene's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 65 mg | 65 mg | Every 6h | PO | Maximum dose 390 mg/day. Frequency may be increased to 8 times if needed. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dextropropoxyphene in overdosage may give rise to further complications which include Sinus tachycardia , Hypotension , Hypotension , Orthostatic hypotension , Seizures , Dependence , Cholestasis , Psychosis , Sinus bradycardia , Syncope , Decreased libido , Biliary obstruction.
Dextropropoxyphene produces potentially life-threatening effects which include Convulsions . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Dextropropoxyphene are Hypotension, Cardiac arrhythmias, Pulmonary edema , Convulsions , Coma, Drowsiness, Drowsiness, Psychotic reactions, Anorectal Reactions, Respiratory depression, Ataxia, Miosis, Respiratory depression, Circulatory collapse, Respiratory depression.
Dextropropoxyphene is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Blurred vision, Confusion, Constipation , Diaphoresis, dizziness, Drowsiness, Dysphoria , Elevation of liver enzymes, Flushing, Headache, Hyponatremia, Jaundice , Malaise, Nausea, Palpitation, Pruritus , Restlessness, Sedation , Skin rashes, Urinary RetentionX, Vision disturbances, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.2.2 — Opioid analgesics