loteprednol

Drug #2285

loteprednol (as Loteprednol Etabonate) contains a sterile, topical anti-inflammatory corticosteroid for ophthalmic use. Loteprednol etabonate is a white to off white powder.chemically it is chloromethyl 17a-[(ethoxycarbonyl)oxy]-11ß-hydroxy-3-oxoandrosta-1,4-diene-17ß-carboxylate. It is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the eye.

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Primary Characteristics

It is of Synthetic origin and belongs to Corticosteroids.

Molecular Weight: 394.88 · Non-proprietary name: loteprednol.

Pharmacokinetics

Elimination: it is metabolised via extensive.

Indications

loteprednol is primarily indicated in conditions like Acne rosacea, Conjunctivitis, Herpes zoster, Iritis, Keratitis, Uveitis.

Contraindications

None recorded.

Dosage

loteprednol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1.5 %	1.5 %	Every 6h	opthalmic	Seasonal Allergic Conjunctivitis
1.5 %	1.5 %	Every 6h	opthalmic	Inflammatory Ocular Disorders
1.5 %	1.5 %	Every 6h	opthalmic	Post Operative Ocular Inflammation
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

loteprednol is known to cause more or less tolerable side effects which are usually transient. These include anterior chamber inflammation, elevated intraocular presure, Eye Pain , Foreign body sensation, herpes simplex, posterior subcapsular cataract formation.

Warnings / Precautions

Intraocular pressure (IOP) increase - Prolonged use of corticosteroids may result in glaucoma with damage to theoptic nerve, defects in visual acuity and fields of vision. If thisproduct is used for 10 days or longer, IOP should be monitored.Cataracts , delay healing after cataract surgery,bacterial infection, viral infection, funcl infection,patients should not wear contact lenes during their course of therapy with loteprednol.

Available Brands

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Single Ingredient

Eye Drops

0.5 %w/v

Multi-Ingredient Combinations

Eye Drops

0.5 %w/v

Drug Classification

1.21.2.1 — Corticosteroids

Manufacturers

Manufacturers of loteprednol in Pakistan:

Elko