Azilisartan Medoxomil
Azilisartan Medoxomil is a prodrug and selective AT1 subtype Angiotensin II Receptor Antagonist.It is hydrolyzed to Azilisartan in GI tract. It blocks the binding of Angiotensin II to the AT1 receptor in vascular smooth muscle and adrenal gland and inhibits effect of Angiotensin.It is given for the treatment of hypertension
Primary Characteristics
It is of Synthetic origin and belongs to Benziimidazole Carboxylate.
It belongs to Angiotensin-II receptor antagonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 606.62 · Solubility in Water: insoluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Azilisartan Medoxomil.
Pharmacokinetics
Absorption: Azilisartan Medoxomil has an oral bioavailability is 30% (±30%).
Distribution: Azilisartan Medoxomil has a plasma protein binding is >99%.
Elimination: it is metabolised via Hepatic, plasma half-life is 11 hours, renal excretion is 42% urine and 55% feces.
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Indications
Azilisartan Medoxomil is primarily indicated in conditions like Hypertension.
Contraindications
Dosage
Azilisartan Medoxomil's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 60 mg | 60 mg | Every 24h | oral | can be taken with or without food |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Azilisartan Medoxomil is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Cough , Diarrhea, Dizziness, Fatigue, GI disorders, muscle spasm, Nausea.
Warnings / Precautions
Available Brands
None recorded.