Eribulin Mesylate
Eribulin Mesylate is a cell cycle specific Anti Cancer drug that belongs to the Class "Non-Taxane microtubule inhibitor".It acts by inhibiting the growth phase of microtubules leading to G2/M cell cylcle blockade, disturption of mitotic spindles and ultimately apoptotic cell death after prolonged mitotic blockade. Eribulin Mesylate is a second choice for metastatic breast cancer that has been previously treated with anthracyclines and taxanes
Primary Characteristics
It is of Synthetic origin and belongs to Non taxane microtubule inhibitor.
It belongs to monoclonal antibody pharmacological group on the basis of mechanism of action.
Molecular Weight: 826 · Non-proprietary name: Eribulin Mesylate.
Pharmacokinetics
Distribution: Eribulin Mesylate has a volume of distribution is 43 L/m2 to 114 L/m2. plasma protein binding is 49-65%.
Elimination: it is metabolised via <0.6% metabolized, plasma half-life is 40 hr, renal excretion is 9% of which 91% in unchanged form.
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Indications
Eribulin Mesylate is primarily indicated in conditions like Locally advanced or metastatic pancreatic cancer, Metastatic breast cancer.
Contraindications
None recorded.
Dosage
Eribulin Mesylate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.23 mg/msq | 1.23 mg/msq | — | I/V | Administer the dose on day 1 and day 8 pf 21 day cycle (vec 2 to 5 min) |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Eribulin Mesylate in overdosage may give rise to further complications which include QT prolongation.
Eribulin Mesylate produces potentially life-threatening effects which include Anemia, Neutropenia , Peripheral neuropathy, Anemia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Eribulin Mesylate are Hypersensitivity reactions, Neutropenia .
Eribulin Mesylate is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Alopecia, Asthenia , Constipation , Depression, dizziness, Dry mouth, dyspepsia, Edema, Fatigue, Hot flushes, Insomnia, Lacrimation, muscle spasm, Nausea, Rashes , Rhinitis , Stomatitis, Tachycardia.
Warnings / Precautions
Available Brands
None recorded.