Lurasidone

Drug #2255

In the year 2011 FDA give regulatory approval to a new drug molecule " Lurasidone" a second generation Antipsychotic drug intended for Schizophrenia. Lurasidone is an Azapiron Derivative and it exhibits its pharmacological effect by acting on the D2 and Serotonin 5HT 2A Receptors as a complete a antagonist. lurasidone also has high affinity for serotonin 5HT7 and it is a partial agonist at 5HT1A receptor. it is believed that these properties can be potentially related to effects on cognition and mood.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzoisothiasole Derivative.

It belongs to D2,Serotonin 5HT2A full Antagonist pharmacological group on the basis of mechanism of action.

Non-proprietary name: Lurasidone.

Pharmacokinetics

Absorption: Lurasidone has an oral bioavailability is 14% (±5%).

Distribution: Lurasidone has a plasma protein binding is 99.8%.

Elimination: it is metabolised via Hepatic, plasma half-life is 18hours, renal excretion is 9% in Urine.

Indications

Lurasidone is primarily indicated in conditions like Psychosis, Schizophrenia.

Contraindications

Lurasidone is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Lurasidone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
60 mg	60 mg	Every 24h	PO	Should be taken with food.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Lurasidone produces potentially life-threatening effects which include Seizures , Suicidal ideation, mortality in elderly patient with dementia. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Lurasidone are elevation of creatinine, Dystonia, Akathisia , Somnolence, parkinsonism.

Lurasidone is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Akathisia, Nausea, Orthostatic hypotension, Weight changes.

Warnings / Precautions

Dose should not exceed 40mg in patients of severe Renal impairment and with moderate-severe hepatic impairment. Greater frequency of parkinsinism and dsytonia , when dose increase to 120mg/d It should be taken with precaution in pregnancy

Available Brands

None recorded.

Drug Classification

1.24.1 — Drugs used in psychotic disorders