Carglumic Acid

Also known as: N-Carbamoyl-L-Glutamic Acid

Drug #2254

Carglumic Acid or N-carbamoyl L-Glutamic Acid is an aminoacid and is an structural analogue of N-Acetylglutamate that acts by activating carbamoyl Phosphate synthetase enzyme which catalyzes the formation of Arginine and Urea from ammonia and thereby lowers blood ammonia level.Carglumic acid is indicated for the treatment of hyperammonemia and hyperglutamenemia due to N-Acetylglutamate synthetase (NAGS) deficiency

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Primary Characteristics

Carglumic Acid is also known as N-Carbamoyl-L-Glutamic Acid.

It belongs to N-Acetyl Glutamate.

Molecular Weight: 190 · Non-proprietary name: Carglumic Acid.

Pharmacokinetics

Elimination: it is metabolised via not metabolized in liver, plasma half-life is 5.6 hr, renal excretion is 9% unchanged in urine and 60% unchanged in feces.

Indications

Carglumic Acid is primarily indicated in conditions like Hyperammonemia.

Contraindications

None recorded.

Dosage

Carglumic Acid's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
175 mg/kg/day	175 mg/kg/day	Every 12h	oral	Each 200 mg should be dispersed in 2.5 ml of water and taken immediately. It shoild be taken before meal. It should not be swallowed whole or crushed
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Carglumic Acid produces potentially life-threatening effects which include Anemia, Infection. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Carglumic Acid are Tachycardia , Restlessness , Sweating , Increased bronchial secretion.

Carglumic Acid is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Ear disorders, Headache, Nasopharyngitis, Pyrexia , Tonsilitis, Vomiting .