Dexfenfluramine (HCl) - Drug Monograph

Primary Characteristics

It is of Synthetic origin and belongs to Fenfluramine.

It belongs to Seletive Serotonin Reuptake Inhibitor , Anorectic Agent pharmacological group on the basis of mechanism of action and also classified in Obesity pharmacological group.

Molecular Weight: 267.7 · pK_a: 9.1 · Solubility in Water: 1 in 10 · Solubility in Alcohol: 1 in 3 · Non-proprietary name: Dexfenfluramine (HCl).

Molecular structure of Dexfenfluramine (HCl)

Pharmacokinetics

Absorption: Dexfenfluramine (HCl) has an oral bioavailability is 85% (±6%), pre-systemic (first-pass) metabolism accounts for 17% (±6%).

Distribution: Dexfenfluramine (HCl) has a volume of distribution is 1000 litre. plasma protein binding is 40.7%.

Elimination: it is metabolised via extensive, plasma half-life is 18.3 hr, renal excretion is 90%.

Indications

Dexfenfluramine (HCl) is primarily indicated in conditions like Eating behavior disorders, Obesity.

Contraindications

Dexfenfluramine (HCl) is contraindicated in conditions like Glucoma.

Dosage

Dexfenfluramine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
15 mg	15 mg	Every 12h	PO	(doses above 30mg/day are not recommended)
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dexfenfluramine (HCl) produces potentially life-threatening effects which include Pulmonary hypertension, Valvulary heart defects. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Dexfenfluramine (HCl) are Tachycardia , Convulsions , Restlessness , Ventricular arrhythmias, Excitement.

Dexfenfluramine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Dizziness, Drowsiness, Dry mouth, Fatigue, Headache, Nausea, Polyuria, Vomiting , Xerostomia .

Warnings / Precautions

Dexfenfluramine should be avoided in patients with pulmonary hypertension, past or current history of cardiovascular or cerebrovascular disease, psychiatric disease, glaucoma, epilepsy, history of drug abuse. It should be used with extreme caution in elderly or during pregnancy or lactation. Avoid abrupt withdrawl. Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness, extreme fatigue and depression. It should be used with caution and monitor blood pressure in patients with mild hypertension. Dose titration and dose discontinuance may be necessary in epileptic patients.

Interference in Pathology

Dexfenfluramine (HCl) may interfere in the diagnosis of False +ve urine drug test.

Available Brands

None recorded.

Storage Conditions

Dexfenfluramine (HCl) should be stored Caps.

Drug Classification

1.17.10 — Antiobesity preparations