Dexamphetamine (Sulphate)

Also known as: Dexamfetamine (Sulphate), Dextro Amphetamine Sulphate

Drug #223

Dexamphetamine (Sulphate) used in the treatment of nacrolepsy and as an adjunct in the management of hyperactivity disorders in childrens (above the age of 6 years).

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Primary Characteristics

Dexamphetamine (Sulphate) is also known as Dexamfetamine (Sulphate), Dextro Amphetamine Sulphate.

It is of Synthetic origin and belongs to Phenylethylamine.

It belongs to Amine release pharmacological group on the basis of mechanism of action. It is also classified under CNS Stimulant .

Molecular Weight: 368.5 · pK_a: 9.9 · Solubility in Water: 1 in 10 · Solubility in Alcohol: 1 in 800 · Non-proprietary name: Dexamphetamine (Sulphate).

Molecular structure of Dexamphetamine (Sulphate)

Pharmacokinetics

Distribution: Dexamphetamine (Sulphate) has a volume of distribution is 5 l/kg. plasma protein binding is 15-40%.

Elimination: it is metabolised via hepatic, plasma half-life is 12-13 hr, renal excretion is 5-30%.

Indications

Dexamphetamine (Sulphate) is primarily indicated in conditions like Attention deficit disorders, Narcolepsy.

Contraindications

Dexamphetamine (Sulphate) is contraindicated in conditions like Angina, Diabetes mellitus, Glucoma, Hypertension, Hyperthyroidism, Insomnia, Anorexia, Psychopathic personality, Gille de la tourette syndrome, Cardiovascular disease, Dyskinesia.

Dosage

Dexamphetamine (Sulphate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
7.5 mg	7.5 mg	Every 8h	PO	Initial daose increased if necessary by 5 to 10 mg At weekly intervals to a maxinum of 60mg daily.
Paediatric Dosage (20kg)
5 mg	5 mg	—		Hyperactivity dose may be increased by 5mg at weekly intervals to upper limity of 20mg & 40mg in chi
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown14 interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dexamphetamine (Sulphate) in overdosage may give rise to further complications which include Hallucinations , Hallucinations , Hypertension , Arrythmia.

Dexamphetamine (Sulphate) produces potentially life-threatening effects which include Intracranial hemorrhages, Intracerebral bleeding, Acute Renal Failure , Acute renal failure. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Dexamphetamine (Sulphate) are Convulsions , Hallucinations , Delirium, Hyperpyrexia, Mydriasis, Hyperreflexia , hyperreflexia.

Dexamphetamine (Sulphate) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Blurred vision, Dysphoria , Headache, Insomnia, Irritability, Mydriasis, Nervousness, Palpitation, Sleep disturbancesX, Sweating , Tachycardia, Weight loss, Weight LossX.

Warnings / Precautions

Dexamphetamine should not be used in patients with cardiovascular disease including moderate to severe hypertension, hyperthydoidism, glaucoma, hyperexcitiability, agitated state, history of drug abuse. It is not recommended to use during pregnancy or lactation. It should be used with caution in patients with mild hypertension, impaired kidney function, epilepsy or unstable personality. Weight and height in children should be monitored as growth retardation may occur. Prolonged high dose may need gradual withdrawl as abrupt withdrawl may produce fatigue or mental depression.

Available Brands

None recorded.

Storage Conditions

Dexamphetamine (Sulphate) should be stored Tab.

Drug Classification

1.24.2.1 — Drugs used in depression