Ethisterone

Also known as: Prone, Pranone, Pregnin, Colutoid +5 more

Drug #2232

Ethisterone is a progestogen, the first orally hormone active progestin. Female sex hormone administered in cases of progestrone deficiency also called hydrohydroxy-progestron, pregneninolone.

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Primary Characteristics

Ethisterone is also known as Prone, Pranone, Pregnin, Colutoid, Ethinone, Gestoral, Prodoxan, Produxan, Prolutal.

It is of Synthetic origin and belongs to Testosterone.

Molecular Weight: 312.45 · Solubility in Alcohol: Sparingly · Non-proprietary name: Ethisterone.

Pharmacokinetics

Elimination: it is metabolised via Liver, plasma half-life is 3-6 hr.

Indications

Ethisterone is primarily indicated in conditions like Endometriosis, Gynaecomastia, Menorrhagia.

Contraindications

None recorded.

Dosage

Ethisterone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
500 mg	500 mg	Every 12h	PO	Depending upon the condition or disease the therapy can be given for 3-6 weeks or from 3-9 months.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Ethisterone in overdosage may give rise to further complications which include Amenorrhea, Menstrual disturbances, Vaginal dryness, Reduction in breast size.

Ethisterone produces potentially life-threatening effects which include Known Human, Urogenital System. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Ethisterone are Headache, Gastrointestinal disturbances, inc or dec blood cell count, Hyperglucagonaemia, Rarely chloestatic jaundice, Elevation of LFT values.

Ethisterone is known to cause more or less tolerable side effects which are usually transient. These include Absent thumbs, Ambigous genitalial, Heart defects, Hydrocephaly, Neuraltube defects.

Warnings / Precautions

Ethisterone should be used with caution in conditions which may be adversely affected by fluid retention, such as in cardiovascular, hepatic and renal disorder, migraine and epilepsy, it is should be avoided in marked cardiac, hepatic or renal dysfunction. Should used with care in diabets mellitas should not be given to patients with undiagnosed gential bleeding or androgen dependent tumors.

Interference in Pathology

Ethisterone may interfere in the diagnosis of Effects on carbohydrates, diabetes mellitus developed in patient receiving ethisterone (400mg) for endometriosis, Effects on liver, cholestasis, peliosis, hepatic and hepatic and adenomas have been associated with ethistrone., Effects on the skin, erythema multiforme developed in two patients receiving ethisterone,.

Available Brands

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Multi-Ingredient Combinations

Caps

75 mg

Manufacturers

Manufacturers of Ethisterone in Pakistan:

Bloom