Piperaquine Phosphate
Pipreraquine is 1,3-bis-[4-(7-chloroquinolyl-4)-piperazinyl-1]- propane, is an antimalarial compound belonging to the 4-aminoquinolines. It is a highly liphophilic. Piperaquine Phosphate (PQP) interferes with physiological function of the food vacuole membrane of the trophozoites leading to autophagocytosis of the parasites. It has no marked effect on the ring forms, immature or mature schizonts and the male of female gametocytes.
Primary Characteristics
It is of Synthetic origin and belongs to Bisquinoline.
Molecular Weight: 999.56 · pKa: four i.e. 6.9, 6.2, 5.7 and 5.4. · Non-proprietary name: Piperaquine Phosphate.
Pharmacokinetics
Absorption: Piperaquine Phosphate has an oral bioavailability is 85% (±5%).
Distribution: Piperaquine Phosphate has a volume of distribution is 716 L/kg.
Elimination: plasma half-life is 9.4 days upto 20 days.
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Indications
Piperaquine Phosphate is primarily indicated in conditions like Malaria caused by plasmodium falciparum.
Contraindications
Piperaquine Phosphate is contraindicated in conditions like Pregnancy.
Dosage
Piperaquine Phosphate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 21 mg/Kg | 21 mg/Kg | Every 24h | PO | It is available in combination with dihydroartemisinin. It should be taken with water without food. Doses are given as mg/Kg/day for three days. Maximun 4 tablets each containing 320mg Pipraquine are indicated for upto 100 Kg weight patient. However, there are no data on which to base a dose recommendation in patients weighing >100kg. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Piperaquine Phosphate is known to cause more or less tolerable side effects which are usually transient. These include Abdominal distress, Anorexia , Arthralgia, Asthenia , Cough , Dizziness, Eosinophilia, Headache, Myalgia, Nausea, Pyrexia , QT prolongation, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.6.4.3 — Antimalarials