Dexibuprofen

Also known as: (S)-(+)-Ibuprofen

Drug #2217

Dexibuprofen [S(+)-Ibuprofen] is considered as the pharmacologically active enantiomer of racemic Ibuprofen. Like racemic Ibuprofen, Dexibuprofen is a non-steroidal antiinflammatory drug with analgesic action. Like Ibuprofen, Dexibuprofen acts by inhibiting prostaglandin synthesis.

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Primary Characteristics

Dexibuprofen is also known as (S)-(+)-Ibuprofen.

It is classified in NSAIDs , Analgesic pharmacological group.

Molecular Weight: 206.28 · Solubility in Water: insoluble · Non-proprietary name: Dexibuprofen.

Pharmacokinetics

Distribution: Dexibuprofen has a plasma protein binding is 99%.

Elimination: plasma half-life is 1.8 to 3.5 hours, renal excretion is 90%.

Indications

Dexibuprofen is primarily indicated in conditions like Dental pain, Mild to moderate pain, Osteoarthritis.

Dexibuprofen is also indicated for secondary conditions like Dysmenorrhoea.

Contraindications

Dexibuprofen is contraindicated in conditions like Ulcerative colitis, Impaired hepatic function, Haemorrhagic diathesis, Crohn's disease, Gastric ulcer, Coagulation disorder, Bleeding disorders, Hypersensitivity to the drug, Severe renal impairment.

Dosage

Dexibuprofen's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
600 – 900 mg	—	Every 8h	PO	to a maximum of 12 g daily. for dysmen orhtoea.
300 mg	300 mg	Every 12h	PO	For period (menstrual) pain. It can be taken for three times per day or as 400 mg two times daily.
300 mg	300 mg	Every 8h	PO	For mild to moderate pain:
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dexibuprofen in overdosage may give rise to further complications which include Tinnitus , Bronchospasm , Bronchospasm .

The signs and symptoms that are produced after acute overdosage of Dexibuprofen are Nausea, Vomiting, Abdominal pain, Lethargy, Tinnitus , Tinnitus.

Dexibuprofen is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Diarrhea, Dyspepsia , Fatigue, Headache, Nausea, Vomiting .

Warnings / Precautions

Symptoms or history of gastro-intestinal disease, asthma, impaired hepatic, cardiac or renal function. NSAID may mask infections or temporarily inhibit platelet aggregation. In late pregnancy, as with other NSAIDs, it should be avoided as it may cause premature closure of ductus arteriosus. Dexibuprofen should be used with caution in nursing mothers. Patients with mild to moderate hepatic dysfunction should start therapy at reduced doses and be closely monitored. Dexibuprofen should not be used in patients with severe hepatic dysfunction. The initial dosage should be reduced in patients with mild to moderate impaired renal function. Dexibuprofen should not be used in patients with severe renal dysfunction.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Susp

100 mg 100 mg/5ml

Tabs

200 mg 300 mg 400 mg

Storage Conditions

Dexibuprofen should be stored Tablet.

Drug Classification

1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)

Manufacturers

Manufacturers of Dexibuprofen in Pakistan:

Genome Getz Global Helix ICI Kanel Pharma Medipak Neo Opal S.J.& G Sami Tabros Zanctok