cyclobenzaprine hydrochloride
Cyclobenzaprine hydrochloride is a tricyclic amine salt with the empirical formula C20H21N•HCl. Cyclobenzaprine is a central nervous system (CNS) muscle relaxant intended for short-term use in the treatment of pain, tenderness, and limitation of motion caused by muscle spasms. It is thought to act within the CNS at the brain stem rather than spinal cord levels, although action at the spinal cord level may contribute to some of its skeletal muscle relaxant action.
Primary Characteristics
It belongs to Muscle Relaxants pharmacological group on the basis of mechanism of action.
Molecular Weight: 311.9 · pKa: 8.47 · Solubility in Water: freely · Solubility in Alcohol: sparingly soluble in isopropanol, and insoluble in hydrocarbon solvents · Non-proprietary name: cyclobenzaprine hydrochloride.
Pharmacokinetics
Absorption: cyclobenzaprine hydrochloride has an oral bioavailability is 44% (±11%).
Distribution: cyclobenzaprine hydrochloride has a plasma protein binding is high.
Elimination: it is metabolised via P-450 3A4, 1A2, and, to a lesser extent, 2D6, plasma half-life is 18 Hours, renal excretion is as glucuronides.
Advertisement
Indications
cyclobenzaprine hydrochloride is primarily indicated in conditions like Muscle relaxation, Muscular spasm, Pain.
Contraindications
cyclobenzaprine hydrochloride is contraindicated in conditions like Hyperthyroidism, Congestive heart failure, Hypersensitivity to any component of product.
Dosage
cyclobenzaprine hydrochloride's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 7.5 mg | 7.5 mg | Every 8h | PO | Use of Cyclobenzaprine Hydrochloride for periods longer than two or three weeks is not recommended. Less frequent dosing should be considered for hepatically impaired or elderly patients |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
cyclobenzaprine hydrochloride in overdosage may give rise to further complications which include Irregular heart beat.
cyclobenzaprine hydrochloride produces potentially life-threatening effects which include Hypersensitivity reactions. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of cyclobenzaprine hydrochloride are Nausea, Tachycardia , Hallucinations , Drowsiness, Changes in ECG, Slurred speech, Dizziness, Coma, Severe hypotension, Seizures, Cardiac dysrhythmias, Confusion , Tremor, Vomiting, Ataxia, Agitation, Hypertension.
cyclobenzaprine hydrochloride is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Acid regurgitation, Constipation , Diarrhea, Drowsiness, Dry mouth, Fatigue, Headache, Nausea.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.20 — Muscle relaxants and cholinesterase inhibitors