Lornoxicam
Lornoxicam is a non steroidal anti-inflammatory drug with analgesic properties and belongs to the class of oxicams. Lornoxicam's mode of action is partly based on inhibition of the prostaglandin synthesis (inhibition of the cyclooxygenase enzyme).
Primary Characteristics
It belongs to NSAID, oxicam group.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action.
Molecular Weight: 371.82 · pKa: 13.63 · Solubility in Water: 4.61e-02 g/l · Non-proprietary name: Lornoxicam.
Pharmacokinetics
Absorption: Lornoxicam has an oral bioavailability is 95% (±5%).
Distribution: Lornoxicam has a volume of distribution is 0.2 L/kg. plasma protein binding is 99%.
Elimination: it is metabolised via hepatic metabolism, plasma half-life is 3-5 hours, renal excretion is 42%,Fecal ex.is 51%.
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Indications
Lornoxicam is primarily indicated in conditions like Ankylosing spondylitis, Osteoarthritis, Pain, Rheumatic arthritis.
Contraindications
Lornoxicam is contraindicated in conditions like Hypovolaemia, Peptic ulcer, Cardiac insufficiency, Dehydration, Hepatic impairment, Hypersensitivity, Pregnancy, Lactation, Cerebrovascular hemorrhage, Gastrointestinal hemorrhage, Severe renal impairment.
Dosage
Lornoxicam's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 16 mg | 16 mg | — | IVor IM | limited upto two days, for treatment of osteo arthritis and rheumatoid arthritis |
| 12 mg | 12 mg | Every 12h | oral | Pain |
| 12 mg | 12 mg | Every 3h | oral | for osteoarthritis and rheumatoid arthritis. In 2 or three divided doses up to Maximum of 10mg. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | not recommended in children less than 18 years of age | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Lornoxicam in overdosage may give rise to further complications which include Anemia , Thrombocytopenia , Leucopenia, Hypertension , Anemia, Hypersensitivity, Skin reactions , Palpitation , Anemia .
Lornoxicam produces potentially life-threatening effects which include Hypersensitivity , Gastrointestinal hemorrhage. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Lornoxicam are Coagulopathy, Coma, Nausea, Dizziness, Renal damage, Vomiting, Ataxia.
Lornoxicam is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Agitation , Constipation , Cough , Depression, Diarrhea, Dizziness, Drowsiness, Dry mouth, Dyspepsia , Flatulence, Headache, Hypertension , Hypotension , Insomnia, Leg cramps, Myalgia, Nausea and vomiting, Nervousness, Rhinitis , Somnolence , Tachycardia, Tinnitus, Urticaria, Vertigo.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)