DrugInfoSys

Nepafenac

Also known as: Nepaphenac

Drug #2210

Nepafenacis a topical sterile. It is an NSAID prodrug for ophthalmic use. It is a prodrug of amfenac.

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Primary Characteristics

Nepafenac is also known as Nepaphenac.

It belongs to Amino Benzoyl Benzeacetamide.

Molecular Weight: 254.28 · Non-proprietary name: Nepafenac · pH: 7.4.

Molecular structure of Nepafenac

Pharmacokinetics

None recorded.

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Indications

Nepafenac is primarily indicated in conditions like Cataract surgery, Pain and inflammation.

Contraindications

Nepafenac is contraindicated in conditions like Hypersensitivity.

Dosage

Nepafenac's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.1 %0.1 %Every 8hOpthalmicStart administration before one day to cataract surgery continue it on the day of surgery and for two weeks after surgery.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Nepafenac is known to cause more or less tolerable side effects which are usually transient. These include Capsular opacity, Conjunctival edema, Corneal edema, Dry eye, Eye Pruritis, Headache, Lid margin crusting, Ocular discomfort, Ocular hyperemia, Ocular pain, Ocular pruritus, Photophobia , Tearing, Vitreous detachment.

Warnings / Precautions

There is the potential for cross-sensitivity to acetylsalicylic acid, phenylacetic acid derivatives, and other nonsteroidal anti-inflammatory agents. Therefore, caution should be used when treating individuals who have previously exhibited sensitivities to these drugs. There exists the potential for increased bleeding time due to interference with thrombocyte aggregation. There have been reports that ocularly applied nonsteroidal anti-inflammatory drugs may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery.

Available Brands

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Single Ingredient

Eye Drops
0.1 %w/v

Storage Conditions

Nepafenac should be stored Opthalmic Susp..

Drug Classification

  1. 1.21.2.3 — Non steroidal anti-inflammatory drugs (NSAIDs)

Manufacturers