Prednicarbate
Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes. IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness.
Primary Characteristics
Molecular Weight: 488.24 · Solubility in Water: 5.62e-03 mg/mL · Solubility in Alcohol: freely soluble · Non-proprietary name: Prednicarbate.
Pharmacokinetics
None recorded.
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Indications
Prednicarbate is primarily indicated in conditions like Pruritic manifestations.
Contraindications
Prednicarbate is contraindicated in conditions like Hypersensitivity.
Dosage
Prednicarbate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.1 % | 0.1 % | Every 24h | Topical | 0.1% may be used with caution in pediatric patients 1 year of age or older. The safety and efficacy of drug use for longer than 3 weeks in this population have not been established. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Prednicarbate is known to cause more or less tolerable side effects which are usually transient. These include Allergic contact dermatitis , Burning, Edema, Paresthesias, Pruritus , Rashes , Skin atrophy, Urticaria.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.18.1 — Corticosteroids, systemic