DrugInfoSys

Dutasteride

Also known as: Gil98745

Drug #2199

Dutasteride is a dual 5-alpha-reductase inhibitor, a newly approved drug (Approved 11-20-2001 for treatment of Benign Prostatic Hyperplasia). It is a synthetic 4-azasteroid compound that is a selective inhibitor of both type 1 and type 2 isoforms of steroid 5a-reductase(5AR), an intracellular enzyme that converts testosterone to 5a-dihydrotestosterone(DHT). Dutasteride has shown dramatic success in restoring hair to bald men in trials.

Primary Characteristics

Dutasteride is also known as Gil98745.

Molecular Weight: 528.5 · Solubility in Water: insoluble (0.038ng/ml) · Solubility in Alcohol: soluble · Non-proprietary name: Dutasteride.

Molecular structure of Dutasteride

Pharmacokinetics

Distribution: Dutasteride has a plasma protein binding is 99%.

Elimination: plasma half-life is 5 weeks.

Advertisement

Indications

Dutasteride is primarily indicated in conditions like Benign prostatic hyperplasia, Hair loss.

Contraindications

None recorded.

Dosage

Dutasteride's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.5 mg0.5 mgEvery 24hPOdaily. Can be administered with or without food.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Dutasteride is known to cause more or less tolerable side effects which are usually transient. These include Decrease in libido, Ejaculatory disturbances, Electrolyte imbalance, Gynecomastia, Hypersensitivity reactions, Impotence, Pruritis, Pruritus , Rashes , Urticaria.

Warnings / Precautions

Dutasteride is for use by men only(hepatic impairment). Women who are or who may become pregnant must not handle dutasteride capsules. The medication can be absorbed through the skin and may cause birth defects in the unborn baby. It may cause feminization or deformed male genitals - though it's not known if every fetus will be affected, or if the dosage and timing is relevant. In fetus, more specifically, the distance from the urinary opening to the anus is decreased, the penis looks more like a large clitoris, the testicles are small or not present, the prostate and seminal vesicles are too small and the nipples are swollen like breasts. Do not donate blood until at least 6 months have passed since the last dose of dutasteride is taken to prevent pregnant women from receiving dutasteride through blood transfusion. Dutasteride may cause an initial period of shedding approximately six to eight weeks into treatment. This is a normal response to treatment with dutasteride. Take dutasteride exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take each dose with a full glass of water. Take the missed dose as soon as you remember during the same day. However, if you don't remember until the next day, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of the medication. Seek emergency medical attention in case of over dose or double dose. Symptoms of a dutasteride overdose are not known.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

Multi-Ingredient Combinations

Drug Classification

  1. 1.29Drugs used in renal, bladder, and prostatic disorders

Manufacturers

Manufacturers of Dutasteride in Pakistan: