Dutasteride
Also known as: Gil98745
Dutasteride is a dual 5-alpha-reductase inhibitor, a newly approved drug (Approved 11-20-2001 for treatment of Benign Prostatic Hyperplasia). It is a synthetic 4-azasteroid compound that is a selective inhibitor of both type 1 and type 2 isoforms of steroid 5a-reductase(5AR), an intracellular enzyme that converts testosterone to 5a-dihydrotestosterone(DHT). Dutasteride has shown dramatic success in restoring hair to bald men in trials.
Primary Characteristics
Dutasteride is also known as Gil98745.
Molecular Weight: 528.5 · Solubility in Water: insoluble (0.038ng/ml) · Solubility in Alcohol: soluble · Non-proprietary name: Dutasteride.

Pharmacokinetics
Distribution: Dutasteride has a plasma protein binding is 99%.
Elimination: plasma half-life is 5 weeks.
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Indications
Dutasteride is primarily indicated in conditions like Benign prostatic hyperplasia, Hair loss.
Contraindications
None recorded.
Dosage
Dutasteride's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 0.5 mg | 0.5 mg | Every 24h | PO | daily. Can be administered with or without food. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dutasteride is known to cause more or less tolerable side effects which are usually transient. These include Decrease in libido, Ejaculatory disturbances, Electrolyte imbalance, Gynecomastia, Hypersensitivity reactions, Impotence, Pruritis, Pruritus , Rashes , Urticaria.
Warnings / Precautions
Available Brands
Drug Classification
- 1.29 — Drugs used in renal, bladder, and prostatic disorders
Manufacturers
Manufacturers of Dutasteride in Pakistan: