Doxofylline
Also known as: Doxofyllinum, Doxofilina
Doxofylline (7-(1,3-dioxalan-2-ylmethyl) theophylline) is a novel xanthine bronchodilator which vary from theophylline in that it contains a dioxalane group in position 7. Similarly to theophylline, its mechanism of action is associated to the inhibition of phosphodiesterase behavior. Doxofylline is shown to have similar efficacy with notably less adverse effects in both animal studies as well as human adults. However, there is a lack of studies in children with asthma. Retrospective data imply that 11% patients experienced some adverse effects, but only 5% reported moderate adverse effects.
Primary Characteristics
Doxofylline is also known as Doxofyllinum, Doxofilina.
It is of Synthetic origin and belongs to (7-(1,3-dioxalan-2-ylmethyl) theophylline).
It belongs to Phosphodiesterase inhibitor pharmacological group on the basis of mechanism of action and also classified in Bronchodilator pharmacological group.
Molecular Weight: 266.3 · Solubility in Water: soluble · Non-proprietary name: Doxofylline · pH: 7.4.
Pharmacokinetics
Distribution: Doxofylline has a plasma protein binding is 48%.
Elimination: plasma half-life is 7.42 hours, renal excretion is less than 4%.
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Indications
Doxofylline is primarily indicated in conditions like Bronchial asthma, Bronchospasm, Chronic asthmatic bronchitis.
Contraindications
Doxofylline is contraindicated in conditions like Acute myocardial infarction, Hypersensitivity to xanthine derivatives.
Dosage
Doxofylline's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 800 mg | 800 mg | Every 24h | ||
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Doxofylline in overdosage may give rise to further complications which include Seizures , Arrythmia, low blood sugar.
The signs and symptoms that are produced after acute overdosage of Doxofylline are Convulsions , Paroxysmal spasm crises, Metabolic acidosis, Rhabdomyolysis , Arrhythmias.
Doxofylline is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Contractions , Headache, Heart burn, Hyperglycemia, Insomnia, Irritability, Nausea, Proteinuria , Shortening of breath, Tachycardia, Vomiting .
Warnings / Precautions
Interference in Pathology
Doxofylline may interfere in the diagnosis of Gastric & Liver ulser, Serious short of O2 supply pateint.
Available Brands
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Single Ingredient
Drug Classification
- 1.25.1.1 — Oral/Parenteral antiasthmatics