Telbivudine

Drug #2192

The FDA approved telbivudine in September 2000. it is used for the treatment of chronic hepatitis B in adults. In patients with active disease, it prevents the hepatitis virus from replicating. The hepatitis B virus uses an enzyme called reverse transcriptase to make DNA and replicate. Telbivudine is an antiretroviral drug. It binds to reverse transcriptase and is incorporated into the DNA strand that the enzyme is making. This process stops the enzyme from extending the length of the DNA strand, and thereby prevents the viruses from replicating

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Primary Characteristics

It is of Synthetic origin.

It belongs to Antiviral Agents pharmacological group on the basis of mechanism of action and also classified in Antiretroviral Agent-Nucleoside pharmacological group.

Non-proprietary name: Telbivudine.

Pharmacokinetics

Elimination: renal excretion is Urine.

Indications

Telbivudine is primarily indicated in conditions like Hepatitis B.

Contraindications

Telbivudine is contraindicated in conditions like Myopathy.

Dosage

None recorded.

Drug Interactions

None recorded.

Side Effects

Telbivudine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Cough , Elevation of CPK , Fatigue, Headache, Malaise, Nasopharyngitis, Respiratory tract infections.

Warnings / Precautions

Severe worsening of hepatitis B symptoms have been reported in patients who discontinued anti-hepatitis B therapy. Some cases of muscle injury (aches, weakness, and biochemical markers of cell damage) have been reported with telbivudine use several weeks to months after starting therapy. Telbivudine is eliminated primarily by the kidneys. Therefore, doses are often adjusted in people with kidney impairment. Telbivudine does not prevent the transmission of the virus from one person to another.

Available Brands

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Single Ingredient

Tabs

600 mg

Drug Classification

1.6.5.2 — Antiretroviral drugs

Manufacturers

Manufacturers of Telbivudine in Pakistan:

Cirin Novartis WnsFeild